Bibliographic Details
| Title: |
Flare phenomenon in prostate cancer: recent evidence on new drugs and next generation imaging |
| Authors: |
Vincenza Conteduca, Giulia Poti, Paola Caroli, Sabino Russi, Nicole Brighi, Cristian Lolli, Giuseppe Schepisi, Antonino Romeo, Federica Matteucci, Giovanni Paganelli, Paolo Marchetti, Ugo De Giorgi |
| Source: |
Therapeutic Advances in Medical Oncology, Vol 13 (2021) |
| Publisher Information: |
SAGE Publishing, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Over the years, an increasing proportion of metastatic prostate cancer patients has been found to experience an initial bone flare phenomenon under both standard therapies (androgen deprivation therapy, chemotherapy, radiotherapy, abiraterone, enzalutamide) and novel agents (immunotherapy, bone-targeting radioisotopes). The underlying biological mechanisms of the flare phenomenon are still elusive and need further clarification, particularly in relation to different types of treatment and their treatment response assessment. Flare phenomenon is often underestimated and, in some cases, can negatively affect clinical outcome. In cases with suspected bone flare, the treatment should be continued for a minimum of 12 more weeks before further decisions about efficacy can be taken. Physicians and patients should be aware of this effect to avoid unwarranted anxiety and inadequate early discontinuation of treatment. This review aims at highlighting new evidence on flare phenomenon arising after the introduction of new drugs extending across the biochemical, radiographic and clinical spectrum of the disease. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1758-8359
17588359 |
| Relation: |
https://doaj.org/toc/1758-8359 |
| DOI: |
10.1177/1758835920987654 |
| Access URL: |
https://doaj.org/article/6358497e9f7348b1ba7829da89a45252 |
| Accession Number: |
edsdoj.6358497e9f7348b1ba7829da89a45252 |
| Database: |
Directory of Open Access Journals |
