Dynamics of pseudo‐atrophy in RRMS reveals predominant gray matter compartmentalization

Bibliographic Details
Title:	Dynamics of pseudo‐atrophy in RRMS reveals predominant gray matter compartmentalization
Authors:	Nicola De Stefano, Antonio Giorgio, Giordano Gentile, Maria Laura Stromillo, Rosa Cortese, Claudio Gasperini, Andrea Visconti, Maria Pia Sormani, Marco Battaglini
Source:	Annals of Clinical and Translational Neurology, Vol 8, Iss 3, Pp 623-630 (2021)
Publisher Information:	Wiley, 2021.
Publication Year:	2021
Collection:	LCC:Neurosciences. Biological psychiatry. Neuropsychiatry LCC:Neurology. Diseases of the nervous system
Subject Terms:	Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
More Details:	Abstract Objective To assess the dynamics of “pseudo‐atrophy,” the accelerated brain volume loss observed after initiation of anti‐inflammatory therapies, in patients with multiple sclerosis (MS). Methods Monthly magnetic resonance imaging (MRI) data of patients from the IMPROVE clinical study (NCT00441103) comparing relapsing‐remitting MS patients treated with interferon beta‐1a (IFNβ‐1a) for 40 weeks versus those receiving placebo (16 weeks) and then IFNβ‐1a (24 weeks) were used to assess percentage of gray (PGMVC) and white matter (PWMVC) volume changes. Comparisons of PGMVC and PWMVC slopes were performed with a mixed effect linear model. In the IFNβ‐1a‐treated arm, a quadratic term was included in the model to evaluate the plateauing effect over 40 weeks. Results Up to week 16, PGMVC was −0.14% per month in the placebo and −0.27% per month in treated patients (P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2328-9503
Relation:	https://doaj.org/toc/2328-9503
DOI:	10.1002/acn3.51302
Access URL:	https://doaj.org/article/634745ee559e4eefb6f235db072155b9
Accession Number:	edsdoj.634745ee559e4eefb6f235db072155b9
Database:	Directory of Open Access Journals

More Details
ISSN:	23289503
DOI:	10.1002/acn3.51302
Published in:	Annals of Clinical and Translational Neurology
Language:	English