Bibliographic Details
| Title: |
Acute exacerbation of progressive pulmonary fibrosis: incidence and outcomes |
| Authors: |
Min Jee Kim, Jiyoul Yang, Jin Woo Song |
| Source: |
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the respiratory system |
| Subject Terms: |
Interstitial lung disease, Progression, Risk factors, Acute exacerbation, Diseases of the respiratory system, RC705-779 |
| More Details: |
Abstract Background Few data are available on acute exacerbation (AE) in patients with progressive pulmonary fibrosis (PPF) besides idiopathic pulmonary fibrosis (IPF). This study aimed to investigate the AE incidence and outcomes among patients with PPF. Methods Clinical data of patients with PPF (n = 133) were retrospectively collected at a single center. PPF was defined based on the criteria used in the INBUILD trial. AE was defined as a worsening of dyspnea typically within 30 days with new bilateral lung infiltration and no evidence of cardiac failure or fluid overload. Results Among patients with PPF, the mean age was 60.6 years old, 57.1% were females, and the most common etiology was connective tissue disease-related ILDs (63%). During the follow-up (median: 38.0 months) after PPF diagnosis, 42 patients (31.6%) experienced AE. The 1-, 3-, and 5-year AE incidences were 12.5%, 30.3%, and 38.0%, respectively. Older age, rheumatoid arthritis associated ILD, fibrotic hypersensitivity pneumonitis, and lower lung diffusing capacity for carbon monoxide were AE risk factors. Patients with AE demonstrated worse survival (median survival: 30 months vs. not reached; p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1465-993X |
| Relation: |
https://doaj.org/toc/1465-993X |
| DOI: |
10.1186/s12931-024-03048-x |
| Access URL: |
https://doaj.org/article/633b88819cd048cfb654010aa95b7c75 |
| Accession Number: |
edsdoj.633b88819cd048cfb654010aa95b7c75 |
| Database: |
Directory of Open Access Journals |
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