Academic Journal
Comparative Outcomes of Primary Versus Recurrent High-risk Non–muscle-invasive and Primary Versus Secondary Muscle-invasive Bladder Cancer After Radical Cystectomy: Results from a Retrospective Multicenter Study
| Title: | Comparative Outcomes of Primary Versus Recurrent High-risk Non–muscle-invasive and Primary Versus Secondary Muscle-invasive Bladder Cancer After Radical Cystectomy: Results from a Retrospective Multicenter Study |
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| Authors: | Nico C. Grossmann, Pawel Rajwa, Fahad Quhal, Frederik König, Hadi Mostafaei, Ekaterina Laukhtina, Keiichiro Mori, Satoshi Katayama, Reza Sari Motlagh, Christian D. Fankhauser, Agostino Mattei, Marco Moschini, Piotr Chlosta, Bas W.G. van Rhijn, Jeremy Y.C. Teoh, Eva Compérat, Marek Babjuk, Mohammad Abufaraj, Pierre I. Karakiewicz, Shahrokh F. Shariat, Benjamin Pradere |
| Source: | European Urology Open Science, Vol 39, Iss , Pp 14-21 (2022) |
| Publisher Information: | Elsevier, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the genitourinary system. Urology LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Urinary bladder neoplasms, Mycobacterium bovis, Recurrence, Disease progression, Survival, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Background: Radical cystectomy (RC) is indicated in primary or secondary muscle-invasive bladder cancer (primMIBC, secMIBC) and in primary or recurrent high- or very high-risk non–muscle-invasive bladder cancer (primHR-NMIBC, recHR-NMIBC). The optimal timing for RC along the disease spectrum of nonmetastatic urothelial carcinoma remains unclear. Objective: To compare outcomes after RC between patients with primHR-NMIBC, recHR-NMIBC, primMIBC, and secMIBC. Design, setting, and participants: This retrospective, multicenter study included patients with clinically nonmetastatic bladder cancer (BC) treated with RC. Outcome measurements and statistical analysis: We assessed oncological outcomes for patients who underwent RC according to the natural history of their BC. primHR-NMIBC and primMIBC were defined as no prior history of BC, and recHR-NMIBC and secMIBC as previously treated NMIBC that recurred or progressed to MIBC, respectively. Log-rank analysis was used to compare survival outcomes, and univariable and multivariable Cox and logistic regression analyses were used to identify predictors for survival. Results and limitations: Among the 908 patients included, 211 (23%) had primHR-NMIBC, 125 (14%) had recHR-NMIBC, 404 (44%) had primMIBC, and 168 (19%) had secMIBC. Lymph node involvement and pathological upstaging were more frequent in the secMIBC group than in the other groups (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2666-1683 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2666168322000544; https://doaj.org/toc/2666-1683 |
| DOI: | 10.1016/j.euros.2022.02.011 |
| Access URL: | https://doaj.org/article/c62fcc5d2989460aaaecd0f907a886be |
| Accession Number: | edsdoj.62fcc5d2989460aaaecd0f907a886be |
| Database: | Directory of Open Access Journals |
| ISSN: | 26661683 |
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| DOI: | 10.1016/j.euros.2022.02.011 |
| Published in: | European Urology Open Science |
| Language: | English |