Optimal Timing of Antiretroviral Therapy Initiation in Acquired Immunodeficiency Syndrome–Associated Toxoplasmic Encephalitis: A Prospective Observational Multicenter Study in China
| Title: | Optimal Timing of Antiretroviral Therapy Initiation in Acquired Immunodeficiency Syndrome–Associated Toxoplasmic Encephalitis: A Prospective Observational Multicenter Study in China |
|---|---|
| Authors: | Yao Li, Haidong Jiang, Yanming Zeng, Yanqiu Lu, Siyuan Chen, Yulin Zhang, Zhongsheng Jiang, Tongtong Yang, Shuiqing Liu, Yaokai Chen, Haijuan Wang |
| Source: | Infectious Diseases & Immunity, Vol 4, Iss 1, Pp 4-9 (2024) |
| Publisher Information: | Wolters Kluwer Health - Lippincott Williams Wilkins, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Infectious and parasitic diseases |
| Subject Terms: | Infectious and parasitic diseases, RC109-216 |
| More Details: | Abstract. Background. Toxoplasmic encephalitis (TE) is the most frequent cause of expansive brain lesions among patients with acquired immunodeficiency syndrome (AIDS). However, the optimal timing of antiretroviral therapy (ART) initiation in these patients remains controversial. This study aims to investigate the differences in outcomes of ART initiation at different times, in order to help clarify the treatment timing of AIDS-associated TE. Methods. This multicenter prospective observational study included 87 patients recruited from 11 research centers in China (from March 2019 to December 2022). Of the patients, 38 were assigned to the early ART group (initiating ART within 2 weeks after anti-Toxoplasma treatment initiation), and the remaining 49 patients received deferred ART (initiating ART at least 2 weeks after anti-Toxoplasma treatment initiation). The main outcomes included mortality and emergence of immune reconstitution inflammatory syndrome (IRIS). Human immunodeficiency virus (HIV)-1 viral load and CD4+ T-cell counts at weeks 24 and 48 were observed. Results. The number of deaths (1 vs. 5, P = 0.225) and incidence of IRIS (2.6% vs. 0, P = 0.437) were not significantly different between the early and deferred ART groups at week 48. Early ART initiation did not contribute significantly to HIV-1 viral load control ( |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2096-9511 2693-8839 00000000 |
| Relation: | http://journals.lww.com/10.1097/ID9.0000000000000105; https://doaj.org/toc/2096-9511; https://doaj.org/toc/2693-8839 |
| DOI: | 10.1097/ID9.0000000000000105 |
| Access URL: | https://doaj.org/article/62f5d05fb38146f59f598577ca3a662d |
| Accession Number: | edsdoj.62f5d05fb38146f59f598577ca3a662d |
| Database: | Directory of Open Access Journals |
| ISSN: | 20969511 26938839 00000000 |
|---|---|
| DOI: | 10.1097/ID9.0000000000000105 |
| Published in: | Infectious Diseases & Immunity |
| Language: | English |