Bibliographic Details
| Title: |
Circulating metabolites improve the prediction of renal impairment in patients with type 2 diabetes |
| Authors: |
Jerzy Adamski, Massimiliano Copetti, Cornelia Prehn, Andrea Fontana, Francesco Paolo Schena, Vincenzo Trischitta, Mario Mastroianno, Maria Giovanna Scarale, Lucia Salvemini, Salvatore De Cosmo, Claudia Menzaghi |
| Source: |
BMJ Open Diabetes Research & Care, Vol 11, Iss 5 (2023) |
| Publisher Information: |
BMJ Publishing Group, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
Introduction Low glomerular filtration rate (GFR) is a leading cause of reduced lifespan in type 2 diabetes. Unravelling biomarkers capable to identify high-risk patients can help tackle this burden. We investigated the association between 188 serum metabolites and kidney function in type 2 diabetes and then whether the associated metabolites improve two established clinical models for predicting GFR decline in these patients.Research design and methods Two cohorts comprising 849 individuals with type 2 diabetes (discovery and validation samples) and a follow-up study of 575 patients with estimated GFR (eGFR) decline were analyzed.Results Ten metabolites were independently associated with low eGFR in the discovery sample, with nine of them being confirmed also in the validation sample (ORs range 1.3–2.4 per 1SD, p values range 1.9×10−2–2.5×10−9). Of these, five metabolites were also associated with eGFR decline (ie, tiglylcarnitine, decadienylcarnitine, total dimethylarginine, decenoylcarnitine and kynurenine) (β range −0.11 to −0.19, p values range 4.8×10−2 to 3.0×10−3). Indeed, tiglylcarnitine and kynurenine, which captured all the information of the other three markers, improved discrimination and reclassification (all p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2052-4897 |
| Relation: |
https://drc.bmj.com/content/11/5/e003422.full; https://doaj.org/toc/2052-4897 |
| DOI: |
10.1136/bmjdrc-2023-003422 |
| Access URL: |
https://doaj.org/article/62f078519dae4dbd99e51123d1aa8177 |
| Accession Number: |
edsdoj.62f078519dae4dbd99e51123d1aa8177 |
| Database: |
Directory of Open Access Journals |
