Bibliographic Details
| Title: |
Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect |
| Authors: |
Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Olivier Bluteau, Sylvie Souquère, Delphine Muller, Khadija M. Diop, Philippe Rameau, Valérie Lapierre, Jean-Pierre Marolleau, Patrick Matthias, Isabelle Godin, Gérard Pierron, Steven G. Thomas, Stephen P. Watson, Nathalie Droin, William Vainchenker, Isabelle Plo, Hana Raslova, Najet Debili |
| Source: |
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
| Publisher Information: |
Nature Portfolio, 2017. |
| Publication Year: |
2017 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Histone deacetylase (HDAC) inhibitors, a class of cancer therapeutics, cause thrombocytopenia via an unknown mechanism. Here, the authors show that HDAC6 inhibition impairs proplatelet formation in human megakaryocytes, and show that this is linked to hyperacetylation of the actin-binding protein cortactin. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-017-01690-2 |
| Access URL: |
https://doaj.org/article/e6244d22664d4e168a0d548e8a713d18 |
| Accession Number: |
edsdoj.6244d22664d4e168a0d548e8a713d18 |
| Database: |
Directory of Open Access Journals |
