Bibliographic Details
| Title: |
Wheezing trajectories from childhood to adulthood in a population-based cohort |
| Authors: |
Priscila Weber, Deborah Jarvis, Ana Maria Baptista Menezes, Helen Gonçalves, Paula Duarte de Oliveira, Fernando C. Wehrmeister |
| Source: |
Allergology International, Vol 71, Iss 2, Pp 200-206 (2022) |
| Publisher Information: |
Elsevier, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
Allergy, Asthma, Population-based cohort, Pulmonary function, Wheezing, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Background: Wheezing may lead to asthma and reduced pulmonary function in later life. The study aims to identify wheezing trajectories and investigate their relation with pulmonary function and asthma-related outcomes at 22 years of age. Methods: Individuals from a population-based cohort in Brazil (1993 Pelotas Birth Cohort) with post-bronchodilator pulmonary function data at 22 years (3350) were included in the study. From parentally reported (4 and 11 years) and self-reported (15, 18 and 22 years) history of wheezing in the last 12 months, we used a group-based trajectory modelling approach to derive wheezing trajectories. Results: Four trajectories were identified: never/infrequent, transient-early, late-onset and persistent wheeze. After adjustments, wheezing trajectories remained associated with lower post-bronchodilator values of pulmonary function. Individuals in the persistent wheeze trajectory had a markedly poorer pulmonary function and also showed greater odds of asthma-related outcomes compared to other trajectories groups. Those following this trajectory had on average −109 ml (95% CI: −188; −35), −1.80 percentage points (95% CI: −2.73; −0.87) and −316 ml/s (95% CI: −482; −150) lower FEV1, FEV1/FVC ratio and FEF25–75% respectively; higher odds of self-reported medical diagnosis of allergy (OR 6.18; 95% CI: 3.59; 10.61) and asthma (OR 12.88; 95% CI: 8.91; 18.61) and asthma medication use (OR 9.42; 95% CI: 5.27; 16.87) compared to the never/infrequent group. Conclusions: Wheezing trajectories, especially the persistent wheeze trajectory, were related to lower pulmonary function values and increased risk of asthma and allergy diagnosis in early adulthood. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1323-8930 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1323893021001222; https://doaj.org/toc/1323-8930 |
| DOI: |
10.1016/j.alit.2021.09.002 |
| Access URL: |
https://doaj.org/article/623036dfdba042b898742525ca69ad14 |
| Accession Number: |
edsdoj.623036dfdba042b898742525ca69ad14 |
| Database: |
Directory of Open Access Journals |
