Bibliographic Details
| Title: |
An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline |
| Authors: |
Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, Ashutosh Tripathy, Sheryl S. Moy, Virginia M. Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-19317-4 |
| Access URL: |
https://doaj.org/article/61ab6286279144ac8d59a59cc0805267 |
| Accession Number: |
edsdoj.61ab6286279144ac8d59a59cc0805267 |
| Database: |
Directory of Open Access Journals |
