Early Markers of Cardiovascular Risk in Autosomal Dominant Polycystic Kidney Disease
| Title: | Early Markers of Cardiovascular Risk in Autosomal Dominant Polycystic Kidney Disease |
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| Authors: | Silvia Lai, Daniela Mastroluca, Silvia Matino, Valeria Panebianco, Antonio Vitarelli, Lidia Capotosto, Irene Turinese, Paolo Marinelli, Marco Rossetti, Alessandro Galani, Pia Baiocchi, Anna R. D’Angelo, Paolo Palange |
| Source: | Kidney & Blood Pressure Research, Vol 42, Iss 6, Pp 1290-1302 (2017) |
| Publisher Information: | Karger Publishers, 2017. |
| Publication Year: | 2017 |
| Collection: | LCC:Dermatology LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: | Autosomal dominant polycystic kidney disease, Cardiovascular risk, Inflammation, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: | Background/Aims: Cardiovascular disease is the most frequent cause of morbidity and mortality in autosomal dominant polycystic kidney disease (ADPKD) patients, often before the onset of renal failure, and the pathogenetic mechanism is not yet well elucidated. The aim of the study was to identify early and noninvasive markers of cardiovascular risk in young ADPKD patients, in the early stages of disease. Methods: A total of 26 patients with ADPKD and 24 control group, matched for age and sex, were enrolled, and we have assessed inflammatory indexes, mineral metabolism, metabolic state and markers of atherosclerosis and endothelial dysfunction (carotid intima media thickness (IMT), ankle brachial index (ABI), flow mediated dilation (FMD), renal resistive index (RRI), left ventricular mass index (LVMI)) and cardiopulmonary exercise testing (CPET), maximal O2 uptake (V’O2max), and O2 uptake at lactic acid threshold (V’O2@LT). Results: The ADPKD patients compared to control group, showed a significant higher mean value of LVMI, RRI, homocysteine (Hcy), Homeostasis Model Assessment-insulin resistance (HOMA-IR), serum uric acid (SUA), Cardiac-troponinT (cTnT) and intact parathyroid hormone (iPTH) (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1420-4096 1423-0143 |
| Relation: | https://www.karger.com/Article/FullText/486011; https://doaj.org/toc/1420-4096; https://doaj.org/toc/1423-0143 |
| DOI: | 10.1159/000486011 |
| Access URL: | https://doaj.org/article/61a7b97007444e94ad6c0a9ab4ec3f05 |
| Accession Number: | edsdoj.61a7b97007444e94ad6c0a9ab4ec3f05 |
| Database: | Directory of Open Access Journals |
| ISSN: | 14204096 14230143 |
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| DOI: | 10.1159/000486011 |
| Published in: | Kidney & Blood Pressure Research |
| Language: | English |