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Post-traumatic Stress Symptoms and Serotonin Transporter (5-HTTLPR) Polymorphism in Breast Cancer Patients

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Title: Post-traumatic Stress Symptoms and Serotonin Transporter (5-HTTLPR) Polymorphism in Breast Cancer Patients
Authors: Luigi Zerbinati, Martino Belvederi Murri, Rosangela Caruso, Maria Giulia Nanni, Wendy Lam, Silvia De Padova, Silvana Sabato, Tatiana Bertelli, Giulia Schillani, Tullio Giraldi, Richard Fielding, Luigi Grassi
Source: Frontiers in Psychiatry, Vol 12 (2021)
Publisher Information: Frontiers Media S.A., 2021.
Publication Year: 2021
Collection: LCC:Psychiatry
Subject Terms: 5-HTTLPR polymorphism, breast cancer, post-traumatic stress symptoms, post-traumatic stress disorder, serotonine transporter, Psychiatry, RC435-571
More Details: Introduction: Post-traumatic Symptoms (PTSS) and Post-traumatic Stress Disorder (PTSD) have been reported to affect a quite significant proportion of cancer patients. No study has examined the relationship between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cancer, including Gene-Environment interactions between this polymorphism and specific causes of distress, such as cancer related problems (CRP) or life stressful events (SLE).Methods: One hundred and forty five breast cancer outpatients participated in the study and were assessed using the Impact of Event Scale (IES), the Problem List (PL) developed by the National Comprehensive Cancer Network (NCCN) Distress Management Guidelines and the Paykel's Life Events Interview to evaluate the exposure to SLE during the year before the cancer diagnosis. Each patient was genotyped for 5-HTTLPR polymorphism by analyzing genomic DNA obtained from whole blood cells. Gene-Environment interactions were tested through moderation analysis.Results: Twenty-six patients (17.7%) were classified as PTSS cases using the IES. Genotype and phenotype distributions did not differ across individuals with/without PTSS (genotype: χ2 = 1.5; df = 2; p = 0.3; phenotype χ2 = 0.9; df = 1; p = 0.2). For both the genotype and phenotype model, using CRP as a predictor showed significant gene-environment interactions with IES total score (p = 0.020 and p = 0.004, respectively), with individuals carrying the l/l allele showing a greater probability of experiencing PTSS. No interaction was found in relationship to SLE (p = 0.750).Conclusion: This study showed a significant GEI between CRP and PTSS in breast cancer patients, with carriers of the l/l allele showing indicators consistent with greater sensitivity to stress.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-0640
Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2021.632596/full; https://doaj.org/toc/1664-0640
DOI: 10.3389/fpsyt.2021.632596
Access URL: https://doaj.org/article/618fc3b335694dd99980493fce0411f5
Accession Number: edsdoj.618fc3b335694dd99980493fce0411f5
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  Data: Post-traumatic Stress Symptoms and Serotonin Transporter (5-HTTLPR) Polymorphism in Breast Cancer Patients
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  Data: <searchLink fieldCode="AR" term="%22Luigi+Zerbinati%22">Luigi Zerbinati</searchLink><br /><searchLink fieldCode="AR" term="%22Martino+Belvederi+Murri%22">Martino Belvederi Murri</searchLink><br /><searchLink fieldCode="AR" term="%22Rosangela+Caruso%22">Rosangela Caruso</searchLink><br /><searchLink fieldCode="AR" term="%22Maria+Giulia+Nanni%22">Maria Giulia Nanni</searchLink><br /><searchLink fieldCode="AR" term="%22Wendy+Lam%22">Wendy Lam</searchLink><br /><searchLink fieldCode="AR" term="%22Silvia+De+Padova%22">Silvia De Padova</searchLink><br /><searchLink fieldCode="AR" term="%22Silvana+Sabato%22">Silvana Sabato</searchLink><br /><searchLink fieldCode="AR" term="%22Tatiana+Bertelli%22">Tatiana Bertelli</searchLink><br /><searchLink fieldCode="AR" term="%22Giulia+Schillani%22">Giulia Schillani</searchLink><br /><searchLink fieldCode="AR" term="%22Tullio+Giraldi%22">Tullio Giraldi</searchLink><br /><searchLink fieldCode="AR" term="%22Richard+Fielding%22">Richard Fielding</searchLink><br /><searchLink fieldCode="AR" term="%22Luigi+Grassi%22">Luigi Grassi</searchLink>
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  Data: Frontiers in Psychiatry, Vol 12 (2021)
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  Data: Frontiers Media S.A., 2021.
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  Data: <searchLink fieldCode="DE" term="%225-HTTLPR+polymorphism%22">5-HTTLPR polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22breast+cancer%22">breast cancer</searchLink><br /><searchLink fieldCode="DE" term="%22post-traumatic+stress+symptoms%22">post-traumatic stress symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22post-traumatic+stress+disorder%22">post-traumatic stress disorder</searchLink><br /><searchLink fieldCode="DE" term="%22serotonine+transporter%22">serotonine transporter</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatry%22">Psychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22RC435-571%22">RC435-571</searchLink>
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  Data: Introduction: Post-traumatic Symptoms (PTSS) and Post-traumatic Stress Disorder (PTSD) have been reported to affect a quite significant proportion of cancer patients. No study has examined the relationship between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and cancer, including Gene-Environment interactions between this polymorphism and specific causes of distress, such as cancer related problems (CRP) or life stressful events (SLE).Methods: One hundred and forty five breast cancer outpatients participated in the study and were assessed using the Impact of Event Scale (IES), the Problem List (PL) developed by the National Comprehensive Cancer Network (NCCN) Distress Management Guidelines and the Paykel's Life Events Interview to evaluate the exposure to SLE during the year before the cancer diagnosis. Each patient was genotyped for 5-HTTLPR polymorphism by analyzing genomic DNA obtained from whole blood cells. Gene-Environment interactions were tested through moderation analysis.Results: Twenty-six patients (17.7%) were classified as PTSS cases using the IES. Genotype and phenotype distributions did not differ across individuals with/without PTSS (genotype: χ2 = 1.5; df = 2; p = 0.3; phenotype χ2 = 0.9; df = 1; p = 0.2). For both the genotype and phenotype model, using CRP as a predictor showed significant gene-environment interactions with IES total score (p = 0.020 and p = 0.004, respectively), with individuals carrying the l/l allele showing a greater probability of experiencing PTSS. No interaction was found in relationship to SLE (p = 0.750).Conclusion: This study showed a significant GEI between CRP and PTSS in breast cancer patients, with carriers of the l/l allele showing indicators consistent with greater sensitivity to stress.
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      – SubjectFull: breast cancer
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