Bibliographic Details
| Title: |
Current understanding of the interplay between extracellular matrix remodelling and gut permeability in health and disease |
| Authors: |
Aurora Vilardi, Stefan Przyborski, Claire Mobbs, Alessandro Rufini, Cristina Tufarelli |
| Source: |
Cell Death Discovery, Vol 10, Iss 1, Pp 1-11 (2024) |
| Publisher Information: |
Nature Publishing Group, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
LCC:Cytology |
| Subject Terms: |
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| More Details: |
Abstract The intestinal wall represents an interactive network regulated by the intestinal epithelium, extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological conditions, the epithelium undergoes constant renewal and forms an integral and selective barrier. Following damage, the healthy epithelium is restored via a series of signalling pathways that result in remodelling of the scaffolding tissue through finely-regulated proteolysis of the ECM by proteases such as matrix metalloproteinases (MMPs). However, chronic inflammation of the gastrointestinal tract, as occurs in Inflammatory Bowel Disease (IBD), is associated with prolonged disruption of the epithelial barrier and persistent damage to the intestinal mucosa. Increased barrier permeability exhibits distinctive signatures of inflammatory, immunological and ECM components, accompanied by increased ECM proteolytic activity. This narrative review aims to bring together the current knowledge of the interplay between gut barrier, immune and ECM features in health and disease, discussing the role of barrier permeability as a discriminant between homoeostasis and IBD. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2058-7716 |
| Relation: |
https://doaj.org/toc/2058-7716 |
| DOI: |
10.1038/s41420-024-02015-1 |
| Access URL: |
https://doaj.org/article/6133f5597d2d47d5bfe6bb010d74c82a |
| Accession Number: |
edsdoj.6133f5597d2d47d5bfe6bb010d74c82a |
| Database: |
Directory of Open Access Journals |
