Plasma CRP level is positively associated with the severity of COVID-19

Bibliographic Details
Title:	Plasma CRP level is positively associated with the severity of COVID-19
Authors:	Wei Chen, Kenneth I. Zheng, Saiduo Liu, Zhihan Yan, Chongyong Xu, Zengpei Qiao
Source:	Annals of Clinical Microbiology and Antimicrobials, Vol 19, Iss 1, Pp 1-7 (2020)
Publisher Information:	BMC, 2020.
Publication Year:	2020
Collection:	LCC:Therapeutics. Pharmacology LCC:Infectious and parasitic diseases LCC:Microbiology
Subject Terms:	SARS-CoV-2, Pneumonia, CRP, CT, Severity, Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
More Details:	Abstract Aims The coronavirus disease 2019 (COVID-19) is characterized as highly contagious and deadly; however there is no credible and convenient biomarker to predict the severity of the disease. The aim of the present study was to estimate whether the CRP level is able to act as a marker in indicating the severity of COVID-19. Methods Patients who complained cough or chest pain with or without fever were enrolled after laboratory confirmed of SARS-CoV-2 viral nucleic acid via qRT-PCR. Chest computed tomography (CT) was then performed to classify the patients into mild, moderate and severe pneumonia groups according to the interim management guideline. Then linear regression models were applied to analyze the association between c-reactive protein (CRP) levels and severity of COVID-19 pneumonia. Results When compared to mild pneumonia, the adjusted-Odds Ratio were 11.46, p = 0.029 and 23.40, p = 0.025 in moderate and severe pneumonia, respectively. The area under receiver operation curve was 0.898 (95% CI 0.835, 0.962, p
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1476-0711
Relation:	http://link.springer.com/article/10.1186/s12941-020-00362-2; https://doaj.org/toc/1476-0711
DOI:	10.1186/s12941-020-00362-2
Access URL:	https://doaj.org/article/6112866124794b22ad993660b83b5853
Accession Number:	edsdoj.6112866124794b22ad993660b83b5853
Database:	Directory of Open Access Journals

More Details
ISSN:	14760711
DOI:	10.1186/s12941-020-00362-2
Published in:	Annals of Clinical Microbiology and Antimicrobials
Language:	English