Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization
| Title: | Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization |
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| Authors: | Jun Jie Piao, Soomin Kim, Dongho Shin, Hwa Jong Lee, Kyung-Hwa Jeon, Wen Jie Tian, Kyung Jae Hur, Jong Soo Kang, Hyun-Je Park, Joo Young Cha, Aeri Song, Sang-Hyuck Park, Mahadevan Rajasekaran, Woong Jin Bae, Sungjoo Kim Yoon, Sae Woong Kim |
| Source: | The World Journal of Men's Health, Vol 43, Iss 1, Pp 228-238 (2025) |
| Publisher Information: | Korean Society for Sexual Medicine and Andrology, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: | cannabidiol, prostatitis, receptor, cannabinoid, cb2, toll-like receptor 4, trpv1 receptor, Medicine, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: | Purpose: This study elucidates the mechanism of the physiological effect of cannabidiol (CBD) by assessing its impact on lipopolysaccharide (LPS)-induced inflammation in RWPE-1 cells and prostatitis-induced by 17β-estradiol and dihydrotestosterone in a rat model, focusing on its therapeutic potential for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Materials and Methods: RWPE-1 cells were stratified in vitro into three groups: (1) controls, (2) cells with LPS-induced inflammation, and (3) cells with LPS-induced inflammation and treated with CBD. Enzyme-linked immunosorbent assays and western blots were performed on cellular components and supernatants after administration of CBD. Five groups of six Sprague– Dawley male rats were assigned: (1) control, (2) CP/CPPS, (3) CP/CPPS and treated with 50 mg/kg CBD, (4) CP/CPPS and treated with 100 mg/kg CBD, and (5) CP/CPPS and treated with 150 mg/kg CBD. Prostatitis was induced through administration of 17β-estradiol and dihydrotestosterone. After four weeks of CBD treatment, a pain index was evaluated, and prostate tissue was collected for subsequent histologic examination and western blot analysis. Results: CBD demonstrated efficacy in vivo for CP/CPPS and in vitro for inflammation. It inhibited the toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway by activating the CB2 receptor, reducing expression of interleukin-6, tumor necrosis factor-alpha, and cyclooxygenase-2 (COX2) (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2287-4208 2287-4690 |
| Relation: | https://doaj.org/toc/2287-4208; https://doaj.org/toc/2287-4690 |
| DOI: | 10.5534/wjmh.230352 |
| Access URL: | https://doaj.org/article/61089c63b778456d901a75fd93d667f8 |
| Accession Number: | edsdoj.61089c63b778456d901a75fd93d667f8 |
| Database: | Directory of Open Access Journals |
| ISSN: | 22874208 22874690 |
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| DOI: | 10.5534/wjmh.230352 |
| Published in: | The World Journal of Men's Health |
| Language: | English |