Bibliographic Details
| Title: |
Metallothionein-3 Increases Triple-Negative Breast Cancer Cell Invasiveness via Induction of Metalloproteinase Expression. |
| Authors: |
Alicja M Kmiecik, Bartosz Pula, Jaroslaw Suchanski, Mateusz Olbromski, Agnieszka Gomulkiewicz, Tomasz Owczarek, Anna Kruczak, Aleksandra Ambicka, Janusz Rys, Maciej Ugorski, Marzena Podhorska-Okolow, Piotr Dziegiel |
| Source: |
PLoS ONE, Vol 10, Iss 5, p e0124865 (2015) |
| Publisher Information: |
Public Library of Science (PLoS), 2015. |
| Publication Year: |
2015 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
It has been recently found that metallothionein-3 (MT3) enhances the invasiveness and tumorigenesis of prostate cancer cells. This finding is in contrast to those of earlier studies, which indicated that overexpression of MT3 in breast cancer and prostate cancer cell lines inhibits their growth in vitro. Therefore, to clarify the role of MT3 in breast cancer progression, we analyzed the effect of MT3-overexpression on proliferation, invasiveness, migration, and tumorigenesis of breast cancer MDA-MB-231/BO2 cells. It was found that MDA-MB-231/BO2 cells overexpressing MT3 were characterized by increased invasiveness in vitro, compared to the control cells. Interestingly, this increased invasiveness correlated with a highly increased concentration of MMP3 in the culture supernatants (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0124865 |
| Access URL: |
https://doaj.org/article/ad60a9f3f7ff4f71992bf9a2ddfe9786 |
| Accession Number: |
edsdoj.60a9f3f7ff4f71992bf9a2ddfe9786 |
| Database: |
Directory of Open Access Journals |
