Bibliographic Details
| Title: |
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe |
| Authors: |
Nicolas Bery, Sandrine Legg, Judit Debreczeni, Jason Breed, Kevin Embrey, Christopher Stubbs, Paulina Kolasinska-Zwierz, Nathalie Barrett, Rose Marwood, Jo Watson, Jon Tart, Ross Overman, Ami Miller, Christopher Phillips, Ralph Minter, Terence H. Rabbitts |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Mutant RAS family members occur in a wide range of tumour types, and there is a great interest in identifying isoform-specific inhibitors. Here, the authors characterise two designed ankyrin repeat proteins (DARPins) that specifically inhibit the KRAS isoform by binding to the region around the KRAS-specific residue histidine 95 and show that they affect KRAS/effector interactions in different ways. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-10419-2 |
| Access URL: |
https://doaj.org/article/d60832bba2a448e1bd87fa3edb2b14fd |
| Accession Number: |
edsdoj.60832bba2a448e1bd87fa3edb2b14fd |
| Database: |
Directory of Open Access Journals |
