Oncogene mutation profile predicts tumor regression and survival in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and radical surgery

Bibliographic Details
Title:	Oncogene mutation profile predicts tumor regression and survival in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and radical surgery
Authors:	Jianhong Peng, Junzhong Lin, Miaozhen Qiu, Yujie Zhao, Yuxiang Deng, Jianyong Shao, Peirong Ding, Huizhong Zhang, Desen Wan, Zhenhai Lu, Zhizhong Pan
Source:	Tumor Biology, Vol 39 (2017)
Publisher Information:	IOS Press, 2017.
Publication Year:	2017
Collection:	LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details:	Tumor response to preoperative chemoradiotherapy and postoperative survival differs among patients with locally advanced rectal cancer. The objective was to find correlations of mutated oncogenes and clinical outcomes in locally advanced rectal cancer. A total of 70 patients with preoperative preoperative chemoradiotherapy followed by radical surgery at a single cancer center between 2006 and 2012 were enrolled. Pretreatment tumor biopsy samples were assayed for 238 mutation hotspots harboring 19 oncogenes by time-of-flight mass spectrometry and OncoCarta Array. Oncogene mutations were found in 48.6% of patients (34/70). KRAS was the most frequent driver mutation, found in 35.7% of patients (25/70), followed by PIK3CA (14.3%), NRAS (5.7%), FLT3 (2.9%), and BRAF (1.4%). Multiple gene mutations were observed in eight patients (11.4%). Tumors with KRAS mutations responded poorly to preoperative chemoradiotherapy (p = 0.044). Patients with oncogene mutations had worse 3-year disease-free survival than those without mutations (67.2% vs 94.2%, p = 0.010). Patients with KRAS or RAS mutations had lower 3-year disease-free survival (68% vs 88.3%, p = 0.016; 65.5% vs 92.3%, p = 0.004, respectively) and 3-year overall survival (88% vs 95.4%, p = 0.020; 89.7% vs 94.9%, p = 0.036, respectively) than those without KRAS or RAS mutations. Oncogene mutation status affected tumor response to treatment and long-term survival in locally advanced rectal cancer.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	1423-0380 10104283
Relation:	https://doaj.org/toc/1423-0380
DOI:	10.1177/1010428317709638
Access URL:	https://doaj.org/article/6014216ac3c9424dabf2e39ad40c0423
Accession Number:	edsdoj.6014216ac3c9424dabf2e39ad40c0423
Database:	Directory of Open Access Journals

More Details
ISSN:	14230380 10104283
DOI:	10.1177/1010428317709638
Published in:	Tumor Biology
Language:	English