Bibliographic Details
| Title: |
Ten-Day Concomitant, 10-Day Sequential, and 7-Day Triple Therapy as First-Line Treatment for Helicobacter pylori Infection: A Nationwide Randomized Trial in Korea |
| Authors: |
Beom Jin Kim, Hyuk Lee, Yong Chan Lee, Seong Woo Jeon, Gwang Ha Kim, Hyun-Soo Kim, Jae Kyu Sung, Dong Ho Lee, Heung Up Kim, Moo In Park, Il Ju Choi, Soon Man Yoon, Sang Wook Kim, Gwang Ho Baik, Ju Yup Lee, Jin Il Kim, Sang Gyun Kim, Jayoun Kim, Joongyup Lee, Jae Gyu Kim, Jae J. Kim, Korean College of Helicobacter Upper Gastrointestinal Research |
| Source: |
Gut and Liver, Vol 13, Iss 5, Pp 531-540 (2019) |
| Publisher Information: |
Gastroenterology Council for Gut and Liver, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: |
concomitant therapy, disease eradication, helicobacter pylori, triple therapy, sequential therapy, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: |
Background/AimsThis nationwide, multicenter prospective randomized controlled trial aimed to compare the efficacy and safety of 10-day concomitant therapy (CT) and 10-day sequential therapy (ST) with 7-day clarithromycin-containing triple therapy (TT) as first-line treatment for Helicobacter pylori infection in the Korean population.Methods : Patients with H. pylori infection were assigned randomly to 7d-TT (lansoprazole 30 mg, amoxicillin 1 g, and clarithromycin 500 mg twice daily for 7 days), 10d-ST (lansoprazole 30 mg and amoxicillin 1 g twice daily for the first 5 days, followed by lansoprazole 30 mg, clarithromycin 500 mg, and metronidazole 500 mg twice daily for the remaining 5 days), or 10d-CT (lansoprazole 30 mg, amoxicillin 1 g, clarithromycin 500 mg, and metronidazole 500 mg twice daily for 10 days). The primary endpoint was eradication rate by intention-to-treat (ITT) and per-protocol (PP) analyses.Results : A total of 1,141 patients were included. The 10d-CT protocol achieved a markedly higher eradication rate than the 7d-TT protocol in both the ITT (81.2% vs 63.9%) and PP analyses (90.6% vs 71.4%). The eradication rate of the 10d-ST protocol was superior to that of the 7d-TT protocol (76.3% vs 63.9%, ITT analysis; 85.0% vs 71.4%, PP analysis). No significant differences in adherence or serious side effects were found among the three treatment arms.Conclusion : sThe 10d-CT and 10d-ST regimens were superior to the 7d-TT regimen as standard first-line treatment in Korea. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1976-2283 |
| Relation: |
http://gutnliver.org/journal/view.html?doi=10.5009/gnl19136; https://doaj.org/toc/1976-2283 |
| DOI: |
10.5009/gnl19136 |
| Access URL: |
https://doaj.org/article/ec5fbce2f68c48448bfc29e408747a21 |
| Accession Number: |
edsdoj.5fbce2f68c48448bfc29e408747a21 |
| Database: |
Directory of Open Access Journals |
