Bibliographic Details
| Title: |
Predictors of reinfection with pre-Omicron and Omicron variants of concern among individuals who recovered from COVID-19 in the first year of the pandemic |
| Authors: |
Dani Cohen, Marina Izak, Evgeniy Stoyanov, Michal Mandelboim, Saritte Perlman, Yonatan Amir, Sophy Goren, Anya Bialik, Limor Kliker, Nofar Atari, Ruti Yshai, Yona Zaide, Hadar Marcus, Noa Madar-Balakirski, Tomer Israely, Nir Paran, Oren Zimhony, Eilat Shinar, Yasmin Maor, Khitam Muhsen |
| Source: |
International Journal of Infectious Diseases, Vol 132, Iss , Pp 72-79 (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Omicron, Pre-omicron variants, Reinfection, Longitudinal study, Hybrid immunity, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Objectives: The predictors of SARS-CoV-2 reinfection are unclear. We examined predictors of reinfection with pre-Omicron and Omicron variants among COVID-19-recovered individuals. Methods: Randomly selected COVID-19-recovered patients (N = 1004) who donated convalescent plasma during 2020 were interviewed between August 2021 and March 2022 regarding COVID-19 vaccination and laboratory-proven reinfection. The sera from 224 (22.3%) participants were tested for antispike (anti-S) immunoglobulin G and neutralizing antibodies. Results: The participants’ median age was 31.1 years (78.6% males). The overall reinfection incidence rate was 12.8%; 2.7% versus 21.6% for the pre-Omicron (mostly Delta) versus Omicron variants. Negative associations were found between fever during the first illness and pre-Omicron reinfection: relative risk 0.29 (95% confidence interval 0.09-0.94), high anti-N level at first illness and Omicron reinfection: 0.53 (0.33-0.85), and overall reinfection: 0.56 (0.37-0.84), as well as between subsequent COVID-19 vaccination with the BNT162b2 vaccine and pre-Omicron 0.15 (0.07-0.32), Omicron 0.48 (0.25-0.45), and overall reinfections 0.38 (0.25-0.58). These variables significantly correlated with immunoglobulin G anti-S follow-up levels. High pre-existing anti-S binding and neutralizing antibody levels against the SARS-CoV-2 Wuhan and Alpha strains predicted protection against Omicron reinfections. Conclusion: Strong immune responses after the first COVID-19 infection and subsequent vaccination with the BNT162b2 vaccine provided cross-protection against reinfections with the Delta and Omicron variants. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S120197122300526X; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2023.04.395 |
| Access URL: |
https://doaj.org/article/5f77e8f9a681427cbd1de9b7349733b8 |
| Accession Number: |
edsdoj.5f77e8f9a681427cbd1de9b7349733b8 |
| Database: |
Directory of Open Access Journals |
