Bibliographic Details
| Title: |
Diagnostic Value of Muscle [11C] PIB-PET in Inclusion Body Myositis |
| Authors: |
Yu-ichi Noto, Masaki Kondo, Yukiko Tsuji, Shigenori Matsushima, Toshiki Mizuno, Takahiko Tokuda, Masanori Nakagawa |
| Source: |
Frontiers in Neurology, Vol 10 (2020) |
| Publisher Information: |
Frontiers Media S.A., 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
inclusion body myositis, idiopathic inflammatory myopathy, dermatomyositis, polymyositis, amyloid, PIB-PET, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Background: The accumulation of multiple-protein aggregates within muscle fibers is a pathological hallmark of sporadic inclusion body myositis (s-IBM) with the presence of inclusion bodies. Amyloid-beta is one of the accumulated proteins in s-IBM. The aim of this study was to elucidate the utility of Pittsburgh compound B-positron emission tomography (PIB-PET) for diagnosing s-IBM.Methods: Nine patients with s-IBM and four patients with idiopathic inflammatory myopathy (IIM) were included. Patients underwent PIB-PET of body muscles. Standardized uptake values (SUVs) were measured in 16 muscles. A comparison of SUVs was made between s-IBM and IIM groups. The correlation between PIB-PET and clinical parameters was analyzed.Results: The mean SUV of all muscles in s-IBM patients was higher than in IIM patients (0.32 vs. 0.25, respectively; p = 0.031). Subgroup analysis identified a clear difference in SUVs of the forearm and lower-leg muscle groups (p = 0.021 and p = 0.045, respectively). There was no correlation between SUVs and clinical parameters in s-IBM patients.Conclusions: Muscle PIB-PET may help to make a diagnosis of s-IBM. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2295 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fneur.2019.01386/full; https://doaj.org/toc/1664-2295 |
| DOI: |
10.3389/fneur.2019.01386 |
| Access URL: |
https://doaj.org/article/5f20bbbc67274c5ea89d0136c01d5267 |
| Accession Number: |
edsdoj.5f20bbbc67274c5ea89d0136c01d5267 |
| Database: |
Directory of Open Access Journals |
