Academic Journal
Pathogenic nsSNPs of protein kinase C-eta with hepatocellular carcinoma susceptibility
| Title: | Pathogenic nsSNPs of protein kinase C-eta with hepatocellular carcinoma susceptibility |
|---|---|
| Authors: | Tayyaba Hussain, Yasmin Badshah, Maria Shabbir, Fizzah Abid, Ghulam Murtaza Kamal, Amna Fayyaz, Janeen H. Trembley, Tayyaba Afsar, Fohad Mabood Husain, Suhail Razak |
| Source: | Cancer Cell International, Vol 24, Iss 1, Pp 1-8 (2024) |
| Publisher Information: | BMC, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| Subject Terms: | nsSNPs, PRKCH, Hepatocellular Carcinoma, ARMS-PCR, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| More Details: | Abstract Background Hepatocellular carcinoma (HCC) is a global health concern. Due to late diagnosis and limited therapeutic strategies, HCC based mortality rate is exponentially increasing globally. Genetic predisposition is a non-avoidable intrinsic factor that could alter the genome sequence, ultimately leading to HCC. Protein kinase C eta (PKCη) is involved in key physiological roles, hence alteration in PKCη could aid in cancer progression. Research indicates association between non-synonymous (ns) SNPs and HCC onset. However, effect of nsSNP variants of PKCη on HCC development has not been explored yet. Hence, this study aimed to investigate the association between pathogenic nsSNPs of PKCη with HCC. Methods Non-synonymous (missense) variants of PKCη were obtained from Ensembl genome browser. These variants were filtered out to obtain pathogenic nsSNPs of PKCη. Genotyping of nsSNPs was done through Tetra ARMS PCR. For that, blood samples of 348 HCC patients and 337 controls were collected. The clinical factors that influence HCC were studied. Relative risk (RR) and Odds Ratio (OR) with 95% confidence interval was calculated by Chi-square test and P-value |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1475-2867 |
| Relation: | https://doaj.org/toc/1475-2867 |
| DOI: | 10.1186/s12935-024-03536-6 |
| Access URL: | https://doaj.org/article/5e3038e4338b4b46ac0340cab2e1ca94 |
| Accession Number: | edsdoj.5e3038e4338b4b46ac0340cab2e1ca94 |
| Database: | Directory of Open Access Journals |
| Full text is not displayed to guests. | Login for full access. |
| ISSN: | 14752867 |
|---|---|
| DOI: | 10.1186/s12935-024-03536-6 |
| Published in: | Cancer Cell International |
| Language: | English |