CAR T-cell therapy for B-cell lymphomas: clinical trial results of available products
| Title: | CAR T-cell therapy for B-cell lymphomas: clinical trial results of available products |
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| Authors: | Julio C. Chavez, Christina Bachmeier, Mohamed A. Kharfan-Dabaja |
| Source: | Therapeutic Advances in Hematology, Vol 10 (2019) |
| Publisher Information: | SAGE Publishing, 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: | Adoptive cellular immunotherapy with chimeric antigen receptor (CAR) T cell has changed the treatment landscape of B-cell non-Hodgkin’s lymphoma (NHL), especially for aggressive B-cell lymphomas. Single-center and multicenter clinical trials with anti-CD19 CAR T-cell therapy have shown great activity and long-term remissions in poor-risk diffuse large B-cell lymphoma (DLBCL) when no other effective treatment options are available. Two CAR T-cell products [axicabtagene ciloleucel (axi-cel) and tisagenlecleucel] have obtained US Food and Drug Administration approval for the treatment of refractory DLBCL after two lines of therapy. A third product, liso-cel, is currently being evaluated in clinical trials and preliminary results appear very promising. CAR T-cell-related toxicity with cytokine-release syndrome and neurotoxicity remain important potential complications of this therapy. Here, we review the s biology, structure, clinical trial results and toxicity of two commercially approved CAR T-cell products and others currently being studied in multicenter clinical trials in B-cell NHLs. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-6215 20406207 |
| Relation: | https://doaj.org/toc/2040-6215 |
| DOI: | 10.1177/2040620719841581 |
| Access URL: | https://doaj.org/article/ee5e1df4d3c04bfcbd734dfc67bbc06f |
| Accession Number: | edsdoj.5e1df4d3c04bfcbd734dfc67bbc06f |
| Database: | Directory of Open Access Journals |
| ISSN: | 20406215 20406207 |
|---|---|
| DOI: | 10.1177/2040620719841581 |
| Published in: | Therapeutic Advances in Hematology |
| Language: | English |