Academic Journal
Baseline risk of hematologic malignancy at initiation of frontline PARP inhibitor maintenance for BRCA1/2-associated ovarian cancer
| Title: | Baseline risk of hematologic malignancy at initiation of frontline PARP inhibitor maintenance for BRCA1/2-associated ovarian cancer |
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| Authors: | Anastasia Navitski, Duaa H. Al-Rawi, Ying Liu, Maria M. Rubinstein, Claire F. Friedman, Raajit K. Rampal, Diana L. Mandelker, Karen Cadoo, Roisin E. O'Cearbhaill |
| Source: | Gynecologic Oncology Reports, Vol 38, Iss , Pp 100873- (2021) |
| Publisher Information: | Elsevier, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Gynecology and obstetrics LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Ovarian cancer, BRCA mutation, PARP inhibitors, Myelodysplastic syndrome, Acute myeloid leukemia, Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Poly(ADP-ribose) polymerase inhibitors (PARPi) are FDA approved as frontline maintenance for BRCA-associated advanced stage high-grade ovarian cancer (HGOC), having demonstrated an unprecedented improvement in relapse-free survival. Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are rare toxicities of PARPi. We describe three patients with germline BRCA-associated (gBRCA+) HGOC and alterations in AML driver genes. Although none evidenced overt hematologic malignancy, PARPi maintenance was cautiously considered given the potential risk of MDS/AML. A better understanding of the role of clonal hematopoiesis in the subsequent development of PARPi-associated MDS/AML will improve management of this patient population. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-5789 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352578921001776; https://doaj.org/toc/2352-5789 |
| DOI: | 10.1016/j.gore.2021.100873 |
| Access URL: | https://doaj.org/article/5dec3a4009954488a69ec3bc6e83b29d |
| Accession Number: | edsdoj.5dec3a4009954488a69ec3bc6e83b29d |
| Database: | Directory of Open Access Journals |
| ISSN: | 23525789 |
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| DOI: | 10.1016/j.gore.2021.100873 |
| Published in: | Gynecologic Oncology Reports |
| Language: | English |