Bibliographic Details
| Title: |
The use of high-frequency short bipolar pulses in cisplatin electrochemotherapy in vitro |
| Authors: |
Scuderi Maria, Rebersek Matej, Miklavcic Damijan, Dermol-Cerne Janja |
| Source: |
Radiology and Oncology, Vol 53, Iss 2, Pp 194-205 (2019) |
| Publisher Information: |
Sciendo, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Medical physics. Medical radiology. Nuclear medicine |
| Subject Terms: |
electroporation, electrochemotherapy, high-frequency bipolar pulses, cisplatin, cell survival, drug uptake, Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| More Details: |
In electrochemotherapy (ECT), chemotherapeutics are first administered, followed by short 100 μs monopolar pulses. However, these pulses cause pain and muscle contractions. It is thus necessary to administer muscle relaxants, general anesthesia and synchronize pulses with the heart rhythm of the patient, which makes the treatment more complex. It was suggested in ablation with irreversible electroporation, that bursts of short high-frequency bipolar pulses could alleviate these problems. Therefore, we designed our study to verify if it is possible to use high-frequency bipolar pulses (HF-EP pulses) in electrochemotherapy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1581-3207 |
| Relation: |
https://doaj.org/toc/1581-3207 |
| DOI: |
10.2478/raon-2019-0025 |
| Access URL: |
https://doaj.org/article/a5db57d1ba4e40c0ba43cfaedb9cd847 |
| Accession Number: |
edsdoj.5db57d1ba4e40c0ba43cfaedb9cd847 |
| Database: |
Directory of Open Access Journals |
