Olfactory Dysfunction in Primary Ciliary Dyskinesia

Bibliographic Details
Title:	Olfactory Dysfunction in Primary Ciliary Dyskinesia
Authors:	Zainab Farzal, Kelli M. Sullivan, Maimoona A. Zariwala, Brian D. Thorp, Brent A. Senior, Charles S. Ebert Jr, Stephanie Davis, Margaret W. Leigh, Michael R. Knowles, Adam J. Kimple
Source:	OTO Open, Vol 9, Iss 1, Pp n/a-n/a (2025)
Publisher Information:	Wiley, 2025.
Publication Year:	2025
Collection:	LCC:Otorhinolaryngology LCC:Surgery
Subject Terms:	chronic rhinosinusitis, motility disorder, primary ciliary dyskinesia, Otorhinolaryngology, RF1-547, Surgery, RD1-811
More Details:	Abstract Objective Individuals with primary ciliary dyskinesia (PCD) frequently report olfactory dysfunction, yet this deficit is poorly documented. The purpose of this study was to characterize the presence and degree of olfactory dysfunction in PCD compared to controls and determine whether certain PCD genes are associated with worse olfaction. Study Design A prospective cohort study. Setting Tertiary referral center. Methods We administered the University of Pennsylvania Smell Identification Test (UPSIT) to individuals with PCD. Participants were divided into 3 age groups (15‐29 years, 30‐44 years, and 45+ years) and compared to age‐ and sex‐matched normal controls (n = 2170). Results Twenty‐nine individuals with PCD (8 males and 21 females) met the criteria (median age: 38 years; interquartile range: 22‐47). Only 27.6% of patients with PCD had UPSIT scores within the normosmia range. The UPSIT median scores of each PCD age group were significantly lower than the median scores of the controls (P
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2473-974X
Relation:	https://doaj.org/toc/2473-974X
DOI:	10.1002/oto2.70084
Access URL:	https://doaj.org/article/5d9cfa33f63743eda8b9c9300ba7b27e
Accession Number:	edsdoj.5d9cfa33f63743eda8b9c9300ba7b27e
Database:	Directory of Open Access Journals

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