Academic Journal
Olfactory Dysfunction in Primary Ciliary Dyskinesia
| Title: | Olfactory Dysfunction in Primary Ciliary Dyskinesia |
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| Authors: | Zainab Farzal, Kelli M. Sullivan, Maimoona A. Zariwala, Brian D. Thorp, Brent A. Senior, Charles S. Ebert Jr, Stephanie Davis, Margaret W. Leigh, Michael R. Knowles, Adam J. Kimple |
| Source: | OTO Open, Vol 9, Iss 1, Pp n/a-n/a (2025) |
| Publisher Information: | Wiley, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Otorhinolaryngology LCC:Surgery |
| Subject Terms: | chronic rhinosinusitis, motility disorder, primary ciliary dyskinesia, Otorhinolaryngology, RF1-547, Surgery, RD1-811 |
| More Details: | Abstract Objective Individuals with primary ciliary dyskinesia (PCD) frequently report olfactory dysfunction, yet this deficit is poorly documented. The purpose of this study was to characterize the presence and degree of olfactory dysfunction in PCD compared to controls and determine whether certain PCD genes are associated with worse olfaction. Study Design A prospective cohort study. Setting Tertiary referral center. Methods We administered the University of Pennsylvania Smell Identification Test (UPSIT) to individuals with PCD. Participants were divided into 3 age groups (15‐29 years, 30‐44 years, and 45+ years) and compared to age‐ and sex‐matched normal controls (n = 2170). Results Twenty‐nine individuals with PCD (8 males and 21 females) met the criteria (median age: 38 years; interquartile range: 22‐47). Only 27.6% of patients with PCD had UPSIT scores within the normosmia range. The UPSIT median scores of each PCD age group were significantly lower than the median scores of the controls (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2473-974X |
| Relation: | https://doaj.org/toc/2473-974X |
| DOI: | 10.1002/oto2.70084 |
| Access URL: | https://doaj.org/article/5d9cfa33f63743eda8b9c9300ba7b27e |
| Accession Number: | edsdoj.5d9cfa33f63743eda8b9c9300ba7b27e |
| Database: | Directory of Open Access Journals |
| ISSN: | 2473974X |
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| DOI: | 10.1002/oto2.70084 |
| Published in: | OTO Open |
| Language: | English |