Bibliographic Details
| Title: |
OnabotulinumtoxinA Add-On to Monoclonal Anti-CGRP Antibodies in Treatment-Refractory Chronic Migraine |
| Authors: |
Andreas A. Argyriou, Emmanouil V. Dermitzakis, Georgia Xiromerisiou, Michail Vikelis |
| Source: |
Toxins, Vol 14, Iss 12, p 847 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
chronic migraine, treatment-refractory migraine, onabotulinumtoxinA, anti-CGRP monoclonal antibodies, dual therapy, Medicine |
| More Details: |
We sought to assess the effectiveness of combining dual therapy with onabotulinumtoxinA (BTX) add-on to anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (anti-CGRP MAbs) in treatment-refractory patients with chronic migraine (CM). We retrospectively reviewed the medical files of 19 treatment-refractory patients with CM who had failed to two oral migraine preventatives, at least three consecutive BTX cycles (less than 30% response rate), at least three consecutive sessions with either fremanezumab or erenumab (less than 30% response rate), and were eventually switched to dual therapy with BTX add-on to any of the already-given anti-CGRP MAbs. We then assessed from baseline to each monotherapy or dual intervention predefined efficacy follow-up the changes in the following efficacy outcomes: (i) monthly headache days (MHD), (ii) monthly days with moderate/severe peak headache intensity, and (iii) monthly days with intake of any acute headache medication. Response (50% reduction in MHD) rates, safety, and tolerability were also determined. In the majority of cases (n = 14), dual targeting proved effective and was associated with clinically meaningful improvement in all efficacy variables; 50% response rates (also disability and QOL outcomes) coupled with favorable safety/tolerability. Our results advocate in favor of the view that dual therapy is effective and should be considered in difficult-to-treat CM patients who have failed all available monotherapies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2072-6651 |
| Relation: |
https://www.mdpi.com/2072-6651/14/12/847; https://doaj.org/toc/2072-6651 |
| DOI: |
10.3390/toxins14120847 |
| Access URL: |
https://doaj.org/article/5d6781b46e144bfe9c61e7aac16dca72 |
| Accession Number: |
edsdoj.5d6781b46e144bfe9c61e7aac16dca72 |
| Database: |
Directory of Open Access Journals |
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