Bibliographic Details
| Title: |
Intratracheal budesonide mixed with surfactant to increase survival free of bronchopulmonary dysplasia in extremely preterm infants: study protocol for the international, multicenter, randomized PLUSS trial |
| Authors: |
Brett J. Manley, C. Omar F. Kamlin, Susan Donath, Li Huang, Pita Birch, Jeanie L. Y. Cheong, Peter A. Dargaville, Jennifer A. Dawson, Lex W. Doyle, Susan E. Jacobs, Rodney Wilson, Peter G. Davis, Christopher J. D. McKinlay |
| Source: |
Trials, Vol 24, Iss 1, Pp 1-18 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
Infant, Extremely preterm, Bronchopulmonary dysplasia, Respiratory distress syndrome, Neonatal intensive care, Pulmonary surfactant, Medicine (General), R5-920 |
| More Details: |
Abstract Background Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks’ gestation and is associated with an increased risk of adverse neurodevelopmental and respiratory outcomes in childhood. Effective and safe prophylactic therapies for BPD are urgently required. Systemic corticosteroids reduce rates of BPD in the short-term but are associated with poorer neurodevelopmental outcomes if given to ventilated infants in the first week after birth. Intratracheal administration of corticosteroid admixed with exogenous surfactant could overcome these concerns by minimizing systemic sequelae. Several small, randomized trials have found intratracheal budesonide in a surfactant vehicle to be a promising therapy to increase survival free of BPD. Methods An international, multicenter, double-blinded, randomized trial of intratracheal budesonide (a corticosteroid) mixed with surfactant for extremely preterm infants to increase survival free of BPD at 36 weeks’ postmenstrual age (PMA; primary outcome). Extremely preterm infants aged |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1745-6215 |
| Relation: |
https://doaj.org/toc/1745-6215 |
| DOI: |
10.1186/s13063-023-07257-5 |
| Access URL: |
https://doaj.org/article/e5d4c1341ef54461a673c1a5d1793472 |
| Accession Number: |
edsdoj.5d4c1341ef54461a673c1a5d1793472 |
| Database: |
Directory of Open Access Journals |
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