Bibliographic Details
| Title: |
Deep phenotyping of 11,880 highlanders reveals novel adaptive traits in native Tibetans |
| Authors: |
Yaoxi He, Wangshan Zheng, Yongbo Guo, Tian Yue, Chaoying Cui, Ouzhuluobu, Hui Zhang, Kai Liu, Zhaohui Yang, Tianyi Wu, Jia Qu, Zi-Bing Jin, Jian Yang, Fan Lu, Xuebin Qi, Bing Su |
| Source: |
iScience, Vol 26, Iss 9, Pp 107677- (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Science |
| Subject Terms: |
Human physiology, Physiology, Anthropology, Science |
| More Details: |
Summary: Tibetans are the ideal population to study genetic adaptation in extreme environments. Here, we performed systematic phenotyping of 11,880 highlanders, covering 133 quantitative traits of 13 organ systems. We provided a comprehensive phenotypic atlas by comparing altitude adaptation and altitude acclimatization. We found the differences between adaptation and acclimatization are quantitative rather than qualitative, with a whole-system “blunted effect” seen in the adapted Tibetans. We characterized twelve different functional changes between adaptation and acclimatization. More importantly, we established a landscape of adaptive phenotypes of indigenous Tibetans, including 45 newly identified Tibetan adaptation-nominated traits, involving specific changes of Tibetans in internal organ state, metabolism, eye morphology, and skin pigmentation. In addition, we observed a sex-biased pattern between altitude acclimatization and adaptation. The generated atlas of phenotypic landscape provides new insights into understanding of human adaptation to high-altitude environments, and it serves as a valuable blueprint for future medical and physiological studies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004223017546; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2023.107677 |
| Access URL: |
https://doaj.org/article/5cd7877ad75d47378e1d144baceb7e8a |
| Accession Number: |
edsdoj.5cd7877ad75d47378e1d144baceb7e8a |
| Database: |
Directory of Open Access Journals |
