| Title: |
Overcoming the myths of esketamine administration: different and not difficult |
| Authors: |
Florian Buchmayer, Siegfried Kasper |
| Source: |
Frontiers in Psychiatry, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Psychiatry |
| Subject Terms: |
esketamine, treatment-resistant, depression, intranasal, TRD (treatment-resistant depression), MDD (major depressive disorder), Psychiatry, RC435-571 |
| More Details: |
Intranasal esketamine for treatment-resistant depression has been introduced and approved by the FDA and EMA in 2019 and 2020, respectively. Since then, the administration practices were found different among countries. Major depression has a high impact on many humans lives worldwide and more than a third of treated people are not responding after several treatment attempts. Additional administration with esketamine closed this gap for more than the half of these non-responders. Guidelines for the treatment of major depression recommend starting with add-on esketamine after 2–4 serious attempts of treatment with standard antidepressants (SSRI/SNRI) irrespective of augmentation with others, e.g., second generation antipsychotics or lithium. Thus, intranasal esketamine became an important role in the evidence-based treatment of major depression. The authors review and critically evaluated published articles focusing on preparation, management and observation of intranasal esketamine treatment. There exists a clear recommendation for administrating intranasal esketamine in a medical environment, not limited to a clinical setting for selecting the dose, monitoring the improvements and managing adverse events. The administration of intranasal esketamine is considered as safe during the application itself and long-lasting or severe adverse events during long-term treatment are very rare. Since this is a new approach for treatment application psychiatrists face new different but not difficult treatment procedures compared to prescribing only a medication. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-0640 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1279657/full; https://doaj.org/toc/1664-0640 |
| DOI: |
10.3389/fpsyt.2023.1279657 |
| Access URL: |
https://doaj.org/article/ace5c98ee4534bc398748df8ae6b0d38 |
| Accession Number: |
edsdoj.5c98ee4534bc398748df8ae6b0d38 |
| Database: |
Directory of Open Access Journals |
