Academic Journal
Current practices and perspectives on the integration of contrast agents in MRI-guided radiation therapy clinical practice: A worldwide survey
| Title: | Current practices and perspectives on the integration of contrast agents in MRI-guided radiation therapy clinical practice: A worldwide survey |
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| Authors: | Luca Boldrini, Filippo Alongi, Angela Romano, Diepriye Charles Davies, Michael Bassetti, Giuditta Chiloiro, Stefanie Corradini, Maria Antonietta Gambacorta, Lorenzo Placidi, Alison C. Tree, Rosalyne Westley, Luca Nicosia |
| Source: | Clinical and Translational Radiation Oncology, Vol 40, Iss , Pp 100615- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Magnetic resonance guided radiation therapy, MRI contrast agents, Radiotherapy planning, Target delineation, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Aims: The introduction of on-line magnetic resonance image-guided radiotherapy (MRIgRT) has led to an improvement in the therapeutic workflow of radiotherapy treatments thanks to the better visualization of therapy volumes assured by the higher soft tissue contrast. Magnetic Resonance contrast agents (MRCA) could improve the target delineation in on-line MRIgRT planning as well as reduce inter-observer variability and enable innovative treatment optimization protocols. The aim of this survey is to investigate the utilization of MRCA among centres that clinically implemented on-line MRIgRT technology. Methods: In September 2021, we conducted an online survey consisting of a sixteen-question questionnaire that was distributed to the all the hospitals around the world equipped with MR Linacs. The questionnaire was developed by two Italian 0.35 T and 1.5 T MR-Linac centres and was validated by four other collaborating centres, using a Delphi consensus methodology. Results: The survey was distributed to 52 centres and 43 centres completed it (82.7%). Among these centres, 23 institutions (53.5%) used the 0.35T MR-Linac system, while the remaining 20 (46.5%) used the 1.5T MR-Linac system.According to results obtained, 25 (58%) of the centres implemented the use of MRCA for on-line MRIgRT. Gadoxetate (Eovist®; Primovist®) was reported to be the most used MRCA (80%) and liver the most common site of application (58%). Over 70% of responders agreed/strongly agreed to the need for international guidelines. Conclusions: The use of MRCA in clinical practice presents several pitfalls and future research will be necessary to understand the actual advantage derived from the use of MRCA in clinical practice, their toxicity profiles and better define the need of formulating guidelines for standardising the use of MRCA in MRIgRT workflow. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-6308 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S240563082300040X; https://doaj.org/toc/2405-6308 |
| DOI: | 10.1016/j.ctro.2023.100615 |
| Access URL: | https://doaj.org/article/5bf02f46cef946dab682d93b30a42df1 |
| Accession Number: | edsdoj.5bf02f46cef946dab682d93b30a42df1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24056308 |
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| DOI: | 10.1016/j.ctro.2023.100615 |
| Published in: | Clinical and Translational Radiation Oncology |
| Language: | English |