Bibliographic Details
| Title: |
Combinatorial immunotherapies overcome MYC-driven immune evasion in triple negative breast cancer |
| Authors: |
Joyce V. Lee, Filomena Housley, Christina Yau, Rachel Nakagawa, Juliane Winkler, Johanna M. Anttila, Pauliina M. Munne, Mariel Savelius, Kathleen E. Houlahan, Daniel Van de Mark, Golzar Hemmati, Grace A. Hernandez, Yibing Zhang, Susan Samson, Carole Baas, Laura J. Esserman, Laura J. van ‘t Veer, Hope S. Rugo, Christina Curtis, Juha Klefström, Mehrdad Matloubian, Andrei Goga |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
The oncoprotein c-Myc is often overexpressed in triple negative breast cancer and has a role in tumor progression and resistance to therapy. Here the authors show that elevated MYC expression is correlated with low immune infiltration, diminished MHC-I pathway expression and that CpG/aOX40 treatment could overcome resistance to PD-L1 blockade in MYC-high breast tumors. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-31238-y |
| Access URL: |
https://doaj.org/article/5ba305a5a1f9497c9247af3f00c75bef |
| Accession Number: |
edsdoj.5ba305a5a1f9497c9247af3f00c75bef |
| Database: |
Directory of Open Access Journals |
