Academic Journal
Spectrally resolved autofluorescence imaging in posterior uveitis
| Title: | Spectrally resolved autofluorescence imaging in posterior uveitis |
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| Authors: | Maximilian W. M. Wintergerst, Nicholas R. Merten, Moritz Berger, Chantal Dysli, Jan H. Terheyden, Enea Poletti, Frank G. Holz, Valentin S. Schäfer, Matthias Schmid, Thomas Ach, Robert P. Finger |
| Source: | Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022) |
| Publisher Information: | Nature Portfolio, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Clinical discrimination of posterior uveitis entities remains a challenge. This exploratory, cross-sectional study investigated the green (GEFC) and red emission fluorescent components (REFC) of retinal and choroidal lesions in posterior uveitis to facilitate discrimination of the different entities. Eyes were imaged by color fundus photography, spectrally resolved fundus autofluorescence (Color-FAF) and optical coherence tomography. Retinal/choroidal lesions’ intensities of GEFC (500–560 nm) and REFC (560–700 nm) were determined, and intensity-normalized Color-FAF images were compared for birdshot chorioretinopathy, ocular sarcoidosis, acute posterior multifocal placoid pigment epitheliopathy (APMPPE), and punctate inner choroidopathy (PIC). Multivariable regression analyses were performed to reveal possible confounders. 76 eyes of 45 patients were included with a total of 845 lesions. Mean GEFC/REFC ratios were 0.82 ± 0.10, 0.92 ± 0.11, 0.86 ± 0.10, and 1.09 ± 0.19 for birdshot chorioretinopathy, sarcoidosis, APMPPE, and PIC lesions, respectively, and were significantly different in repeated measures ANOVA (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-18048-4 |
| Access URL: | https://doaj.org/article/d5b97cf5f3c6445599d347565630d9ba |
| Accession Number: | edsdoj.5b97cf5f3c6445599d347565630d9ba |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-022-18048-4 |
| Published in: | Scientific Reports |
| Language: | English |