Bibliographic Details
| Title: |
Impact of follicular size categories on oocyte quality at trigger day in young and advanced-age patients undergoing GnRH-ant therapy |
| Authors: |
Jingwei Yang, Jing Gao, Yuting Wang, Hongya Liu, Xuemei Lian |
| Source: |
Frontiers in Endocrinology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
follicle size, oocyte quality, advanced age, GnRH-ant cycles, trigger, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
AimTo study the effect of follicle sizes of different proportions on oocyte and embryo quality in young and advanced-age patients, and provide evidence for personalized protocol adjustment.MethodsThis was a retrospective real-world data study including a total of 11,462 patients who had started their first in vitro fertilization cycle with a gonadotropin-releasing hormone antagonist (GnRH-ant) protocol during 2018–2021. We classified patients into groups according to the size of the dominant proportion of follicles on the human chorionic gonadotropin (hCG) trigger day: Large, Medium, Small, and Equal (containing equivalent proportions of all three size categories). The Cochran–Mantel–Haenszel test by different Anti-Mullerian Hormone (AMH) and antral follicle count (AFC) was used to compare factors such as the metaphase II (MII) oocyte rate, normal fertilization rate, and two pronuclei (2PN) cleavage rate between groups. General linear model (GLM) analysis was performed for inter-group comparison of the oocyte and embryo quality.ResultsIn patients aged < 35 years and with AMH ≥ 1.2μg/L, the MII oocyte percentages in the Large and Medium groups were significantly higher than in the Small group (P < 0.001). The germinal vesicle (GV) oocyte and unavailable oocyte percentages in the Large and Medium groups were lower than in the Small group (P < 0.001). Among patients aged ≥ 35 years with AFC < 5 and AMH ≥ 1.2μg/L, the GV oocyte percentage in the Large group was significantly lower than in the Medium group (2.54% vs. 4.46%, P < 0.001). In patients < 35 years, the GLM demonstrated that the Large and Medium groups had positively impacted on the development of MII oocyte and live birth rate(LBR) of first embryo transfer(ET)(β>0, all P value < 0.05);and had less likely to develop into unavailable oocyte, degenerated oocyte, GV oocyte and MI oocyte rates relative to the Small group(β0, all P value < 0.05); and had less likely to develop into MI oocytes relative to the Small group(β |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2023.1167395/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2023.1167395 |
| Access URL: |
https://doaj.org/article/5b4db0c18a404156a73083485acd4804 |
| Accession Number: |
edsdoj.5b4db0c18a404156a73083485acd4804 |
| Database: |
Directory of Open Access Journals |
