Bibliographic Details
| Title: |
Potential protective role of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in COVID-19 |
| Authors: |
Mateus V. de Castro, Leonardo M. Cariste, Rafael R. Almeida, Greyce L. Sasahara, Monize V. R. Silva, Flávia B. Soares, Vivian R. Coria, Michel S. Naslavsky, Keity S. Santos, Edecio Cunha-Neto, Jorge Kalil, Mayana Zatz |
| Source: |
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
IFIT3, COVID-19, innate immunity, SARS-CoV-2, protection, Microbiology, QR1-502 |
| More Details: |
The COVID-19 pandemic has prompted a quest to understand why certain individuals remain uninfected or asymptomatic despite repetitive exposure to SARS-CoV-2. Here, we focused on six exposed females residing with their symptomatic and reinfected SARS-CoV-2 PCR-positive COVID-19 partners. Peripheral blood mononuclear cell samples from couples were analysed for poly (I:C)-induced mRNA expression of type I/III interferons and interferon-stimulated genes (ISGs). Remarkably, we found a significant upregulation of the ISG interferon-inducible protein with tetrapeptide repeats 3 (IFIT3) gene exclusively in exposed uninfected or asymptomatic females, suggesting a potential role in protective immunity against symptomatic COVID-19. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2235-2988 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fcimb.2024.1464581/full; https://doaj.org/toc/2235-2988 |
| DOI: |
10.3389/fcimb.2024.1464581 |
| Access URL: |
https://doaj.org/article/d5aeadc394e74f33a19faa2847f293ba |
| Accession Number: |
edsdoj.5aeadc394e74f33a19faa2847f293ba |
| Database: |
Directory of Open Access Journals |
