Academic Journal
Safety and clinical efficacy of BCMA CAR-T-cell therapy in multiple myeloma
| Title: | Safety and clinical efficacy of BCMA CAR-T-cell therapy in multiple myeloma |
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| Authors: | Gils Roex, Marijke Timmers, Kristien Wouters, Diana Campillo-Davo, Donovan Flumens, Wilfried Schroyens, Yiwei Chu, Zwi N. Berneman, Eva Lion, Feifei Luo, Sébastien Anguille |
| Source: | Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2020) |
| Publisher Information: | BMC, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Diseases of the blood and blood-forming organs LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | BCMA, CAR-T, Multiple myeloma, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Abstract Background B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR)-T-cell therapy is an emerging treatment option for multiple myeloma. The aim of this systematic review and meta-analysis was to determine its safety and clinical activity and to identify factors influencing these outcomes. Methods We performed a database search using the terms “BCMA,” “CAR,” and “multiple myeloma” for clinical studies published between 01/01/2015 and 01/01/2020. The methodology is further detailed in PROSPERO (CRD42020125332). Results Twenty-three different CAR-T-cell products have been used so far in 640 patients. Cytokine release syndrome was observed in 80.3% (69.0–88.2); 10.5% (6.8–16.0) had neurotoxicity. A higher neurotoxicity rate was reported in studies that included more heavily pretreated patients: 19.1% (13.3–26.7; I 2 = 45%) versus 2.8% (1.3–6.1; I 2 = 0%) (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1756-8722 |
| Relation: | https://doaj.org/toc/1756-8722 |
| DOI: | 10.1186/s13045-020-01001-1 |
| Access URL: | https://doaj.org/article/c5abce8e1fbc403397769e67dc74eb91 |
| Accession Number: | edsdoj.5abce8e1fbc403397769e67dc74eb91 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17568722 |
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| DOI: | 10.1186/s13045-020-01001-1 |
| Published in: | Journal of Hematology & Oncology |
| Language: | English |