Academic Journal
Rare severe mycotic infections in children receiving empirical caspofungin treatment for febrile neutropenia
| Title: | Rare severe mycotic infections in children receiving empirical caspofungin treatment for febrile neutropenia |
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| Authors: | Deniz Yilmaz Karapinar, Nihal Karadaş, Zühal Önder Siviş, Pinar Yazici, Muhterem Duyu, Dilek Metin, Bülent Karapinar, Yeşim Aydinok |
| Source: | Brazilian Journal of Infectious Diseases, Vol 19, Iss 5, Pp 549-552 (2015) |
| Publisher Information: | Elsevier, 2015. |
| Publication Year: | 2015 |
| Collection: | LCC:Infectious and parasitic diseases LCC:Microbiology |
| Subject Terms: | Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502 |
| More Details: | Empirical antifungal therapy is most often given to patients with leukemia. However breakthrough fungal infections under antifungal therapy are not uncommon. Four children, with hematologic malignant disease developed mycotic breakthrough infections while on empirical caspofungin treatment for a median of 14 (range 11–19) days. Trichosporon asahii was detected in the blood culture of two patients and Geotrichum capitatum in the other two (one patient also had positive cerebrospinal fluid culture). Because the patients’ clinical situation worsened, voriconazole was empirically added for two patients three and five days before the agent was detected. The first sterile blood culture was obtained 3–7 days of voriconazole treatment. All patients reached clear cultures but one patient died. One patient with central nervous system infection with G. capitatum had severe neurological sequelae. Very severe fungal infections can occur during empirical caspofungin therapy. Therefore, patients should be followed closely. Keywords: Geotrichum capitatum, Trichosporon asahii, Invazive fungal infection, Febrile neutropenia |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1413-8670 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1413867015001312; https://doaj.org/toc/1413-8670 |
| DOI: | 10.1016/j.bjid.2015.06.008 |
| Access URL: | https://doaj.org/article/5abbf3693f2b4fdb9d0fd8ebc8067bbb |
| Accession Number: | edsdoj.5abbf3693f2b4fdb9d0fd8ebc8067bbb |
| Database: | Directory of Open Access Journals |
| ISSN: | 14138670 |
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| DOI: | 10.1016/j.bjid.2015.06.008 |
| Published in: | Brazilian Journal of Infectious Diseases |
| Language: | English |