Bibliographic Details
| Title: |
Neurological and growth outcomes in South African children with congenital cytomegalovirus: A cohort study. |
| Authors: |
Jayani Pathirana, Leanne Texeira, Hannah Munian, Firdose Nakwa, Ismail Mayet, Innocent Maposa, Michelle J Groome, Suresh Boppana, Shabir A Madhi |
| Source: |
PLoS ONE, Vol 15, Iss 9, p e0238102 (2020) |
| Publisher Information: |
Public Library of Science (PLoS), 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
ObjectivesTo assess neurological sequelae and growth in the first 12 months of life in a cohort of congenital cytomegalovirus (cCMV) infected infants compared to cCMV uninfected infants.Study designThis was a prospective matched cohort study conducted in Soweto, South Africa where forty-six confirmed cCMV cases were matched on HIV-exposure, gender and gestational age (±two weeks) to 84 cCMV-uninfected controls in a 1:2 ratio. Cases and controls were followed up until 12 months of age to assess anthropometry, hearing and neurodevelopmental outcomes.ResultsThirty-four (73.9%) cCMV cases and 74 (88.1%) controls, completed all assessments at 12 months age. At 12 months, one cCMV case had died, none of the children in either group had SNHL and neurodevelopmental delay was present in a similar percentage of cCMV cases (n = 2; 6%) and controls (n = 1, 4%; OR 1.09, 95% CI 0.04-27.84, p = 0.958). Anthropometry did not differ between cases and controls overall throughout the follow up period. HIV-exposed cases had smaller head circumference for age at 6 and 12 months when compared with HIV-exposed controls.ConclusionBy 12 months of age, there was no evidence of a difference in neurological sequelae between cCMV infected South African children and cCMV uninfected children in this study. Further follow-up is warranted to detect late-onset hearing loss and neurodevelopmental delay beyond 12 months of age. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1932-6203 |
| Relation: |
https://doaj.org/toc/1932-6203 |
| DOI: |
10.1371/journal.pone.0238102 |
| Access URL: |
https://doaj.org/article/5a4572f82e884aa9b5f15da8bb70b7fd |
| Accession Number: |
edsdoj.5a4572f82e884aa9b5f15da8bb70b7fd |
| Database: |
Directory of Open Access Journals |
