Bibliographic Details
| Title: |
Variation in immunoglobulin use and impact on survival in myeloma |
| Authors: |
Khai Li Chai, Cameron Wellard, LTP Thao, Naomi Aoki, Elizabeth M Moore, Bradley M Augustson, Akshay Bapat, Hilary Blacklock, Wee J Chng, Rachel Cooke, Cecily J Forsyth, Yeow‐Tee Goh, Nada Hamad, Simon J Harrison, P Joy Ho, Jay Hocking, Ian Kerridge, Jin Seok Kim, Kihyun Kim, Tracy King, Georgia J McCaughan, Peter Mollee, C Orla Morrissey, Nick Murphy, Hang Quach, Xuan Ni Tan, Allison CY Tso, Kimberly SQ Wong, Sung‐Soo Yoon, Andrew Spencer, Erica M Wood, Zoe K McQuilten |
| Source: |
eJHaem, Vol 5, Iss 4, Pp 690-697 (2024) |
| Publisher Information: |
Wiley, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: |
immunoglobulin, infection, multiple myeloma, Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: |
Abstract Serious infection is common in patients with multiple myeloma due to immune deficiency from the underlying disease and/or its treatment. Immunoglobulin replacement is one approach to reduce infection risk in these patients. However, few real‐world data exist on its use in patients with myeloma. We investigated immunoglobulin use in Australia, New Zealand and Asia‐Pacific using registry data and explored its association with survival outcomes. A total of 2374 patients with a median follow‐up time of 29.5 months (interquartile range 13.3–54.3 months) were included in the analysis – 1673 from Australia, 313 Korea, 281 New Zealand and 107 Singapore. Overall, 7.1% of participants received immunoglobulin replacement within 24 months of diagnosis. Patients who received immunoglobulin replacement were likely to be younger, had lower baseline IgG levels (excluding paraprotein), were more likely to have baseline hypogammaglobulinaemia, baseline severe hypogammaglobulinaemia and abnormal baseline fluorescent in‐situ hybridisation status, receive first‐line myeloma treatment with immunomodulatory drugs or anti‐CD38 therapy and undergo upfront autologous stem cell transplant. In our patient cohort, the use of immunoglobulin was not associated with overall survival benefit at the time of last follow‐up (adjusted hazard ratio 0.72, 95% CI 0.46–1.14, p = 0.16). Understanding treatment approaches in clinical practice can help support future planning and provision of immunoglobulin resources. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2688-6146 |
| Relation: |
https://doaj.org/toc/2688-6146 |
| DOI: |
10.1002/jha2.938 |
| Access URL: |
https://doaj.org/article/5a24a48b600f4da59acde72c4e4cde39 |
| Accession Number: |
edsdoj.5a24a48b600f4da59acde72c4e4cde39 |
| Database: |
Directory of Open Access Journals |
