Bibliographic Details
| Title: |
Meta-Analysis of Genome-Wide Association and Gene Expression Studies Implicates Donor T Cell Function and Cytokine Pathways in Acute GvHD |
| Authors: |
Kati Hyvärinen, Satu Koskela, Riitta Niittyvuopio, Anne Nihtinen, Liisa Volin, Urpu Salmenniemi, Mervi Putkonen, Ismael Buño, David Gallardo, Maija Itälä-Remes, Jukka Partanen, Jarmo Ritari |
| Source: |
Frontiers in Immunology, Vol 11 (2020) |
| Publisher Information: |
Frontiers Media S.A., 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
GvHD, GWAS, gene expression, meta-analysis, HSCT, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Graft-vs.-host disease (GvHD) is a major complication after allogeneic hematopoietic stem cell transplantation that causes mortality and severe morbidity. Genetic disparities in human leukocyte antigens between the recipient and donor are known contributors to the risk of the disease. However, the overall impact of genetic component is complex, and consistent findings across different populations and studies remain sparse. To gain a comprehensive understanding of the genes responsible for GvHD, we combined genome-wide association studies (GWAS) from two distinct populations with previously published gene expression studies on GvHD in a single gene-level meta-analysis. We hypothesized that genes driving GvHD should be associated in both data modalities and therefore could be detected more readily through their combined effects in the integrated analysis rather than in separate analyses. The meta-analysis yielded a total of 51 acute GvHD-associated genes (false detection rate [FDR] |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fimmu.2020.00019/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2020.00019 |
| Access URL: |
https://doaj.org/article/5a01dc7926d04cf7b717b130211e553b |
| Accession Number: |
edsdoj.5a01dc7926d04cf7b717b130211e553b |
| Database: |
Directory of Open Access Journals |
