Academic Journal
Japan Diabetes Complications Study: Revisiting one of the first large‐scale clinical studies in East Asians with diabetes
| Title: | Japan Diabetes Complications Study: Revisiting one of the first large‐scale clinical studies in East Asians with diabetes |
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| Authors: | Hirohito Sone, Chika Horikawa, Sachiko Tanaka‐Mizuno, Ryo Kawasaki, Kazuya Fujihara, Tatsumi Moriya, Atsushi Araki, Shiro Tanaka, Yasuo Akanuma |
| Source: | Journal of Diabetes Investigation, Vol 16, Iss 3, Pp 360-369 (2025) |
| Publisher Information: | Wiley, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | East Asia, large‐scale clinical study, Lifestyle, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Abstract This review highlights the significance of the Japan Diabetes Complications Study (JDCS), one of the earliest large‐scale studies of people with type 2 diabetes outside Europe and the United States, in understanding type 2 diabetes mellitus among East Asian populations, particularly in Japan. Historically, large‐scale clinical studies on type 2 diabetes mellitus have predominantly focused on Western populations, despite East Asians comprising the largest proportion of diabetic patients globally. The JDCS, which was initiated in 1996, enrolled 2,033 Japanese type 2 diabetes mellitus patients. It aimed to evaluate the effects of intensive lifestyle interventions on diabetic complications. The study demonstrated that lifestyle‐focused interventions significantly reduced the risk of stroke and other complications compared to conventional treatment. Key findings of its sub‐analyses include the unique characteristics of Japanese patients with type 2 diabetes mellitus, such as their lower body mass index (BMI) compared to Western counterparts and a stronger association between even modest BMI increases and beta cell dysfunction. Additionally, the JDCS provided insights into the risk factors for nephropathy, retinopathy, and macrovascular complications, emphasizing the importance of controlling blood pressure, glycemia, and lifestyle factors. The study also explored the impact of diet, exercise, and mental health on diabetic outcomes, revealing the protective effects of physical activity and a balanced diet, while highlighting the risks associated with high salt intake and depression. A risk prediction model tailored to Japanese patients was also developed. Overall, this study made a significant contribution to the evidence‐based management of type 2 diabetes mellitus in East Asia. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-1124 2040-1116 |
| Relation: | https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124 |
| DOI: | 10.1111/jdi.14394 |
| Access URL: | https://doaj.org/article/59f2ef9248ff49a6a1f69be3f30372dc |
| Accession Number: | edsdoj.59f2ef9248ff49a6a1f69be3f30372dc |
| Database: | Directory of Open Access Journals |
| ISSN: | 20401124 20401116 |
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| DOI: | 10.1111/jdi.14394 |
| Published in: | Journal of Diabetes Investigation |
| Language: | English |