Bibliographic Details
| Title: |
Mitochondrial mutation m.3243A>G associates with insulin resistance in non-diabetic carriers |
| Authors: |
Jakob Høgild Langdahl, Anja Lisbeth Frederiksen, John Vissing, Morten Frost, Knud Bonnet Yderstræde, Per Heden Andersen |
| Source: |
Endocrine Connections, Vol 8, Iss 7, Pp 829-837 (2019) |
| Publisher Information: |
Bioscientifica, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
monogenic diabetes, mitochondrial DNA point mutation m.3243A>G, mitochondrial dysfunction, insulin resistance, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
Aim: This case–control study aimed to examine impairments in glucose metabolism in non-diabetic carriers of the mitochondrial mutation m.3243A>G by evaluating insulin secretion capacity and sensitivity. Methods: Glucose metabolism was investigated in 23 non-diabetic m.3243A>G carriers and age-, sex- and BMI-matched healthy controls with an extended 4-h oral glucose tolerance test (OGTT). Insulin sensitivity index and acute insulin response were estimated on the basis of the OGTT. This was accompanied by examination of body composition by dual-energy X-ray absorptiometry (DXA), maximum aerobic capacity and a Recent Physical Activity Questionnaire (RPAQ). Results: Fasting p-glucose, s-insulin and s-c-peptide levels did not differ between m.3243A>G carriers and controls. Insulin sensitivity index (BIGTT-S1) was significantly lower in the m.3243A>G carriers, but there was no difference in the acute insulin response between groups. P-lactate levels were higher in carriers throughout the OGTT. VO2max, but not BMI, waist and hip circumferences, lean and fat body mass%, MET or grip strength, was lower in mutation carriers. BIGTT-S1 remained lower in mutation carriers after adjustment for multiple confounding factors including VO2max in regression analyses. Conclusions: Glucose metabolism in m.3243A>G carriers was characterized by reduced insulin sensitivity, which could represent the earliest phase in the pathogenesis of m.3243A>G-associated diabetes. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2049-3614 |
| Relation: |
https://ec.bioscientifica.com/view/journals/ec/8/7/EC-19-0118.xml; https://doaj.org/toc/2049-3614 |
| DOI: |
10.1530/EC-19-0118 |
| Access URL: |
https://doaj.org/article/59d1205e113740a8a2a33594ac121aba |
| Accession Number: |
edsdoj.59d1205e113740a8a2a33594ac121aba |
| Database: |
Directory of Open Access Journals |
