Antioxidant, Antiviral, and Anti-Inflammatory Activities of Lutein-Enriched Extract of Tetraselmis Species
| Title: | Antioxidant, Antiviral, and Anti-Inflammatory Activities of Lutein-Enriched Extract of Tetraselmis Species |
|---|---|
| Authors: | Eun-A Kim, Nalae Kang, Seong-Young Heo, Jae-Young Oh, Seung-Hong Lee, Seon-Heui Cha, Won-Keun Kim, Soo-Jin Heo |
| Source: | Marine Drugs, Vol 21, Iss 7, p 369 (2023) |
| Publisher Information: | MDPI AG, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Biology (General) |
| Subject Terms: | Tetraselmis sp., antioxidant, antiviral, anti-inflammatory, Biology (General), QH301-705.5 |
| More Details: | Microalgae are proposed to have powerful applications for human health in the pharmaceutical and food industries. Tetraselmis species (sp.), which are green microalgae, were identified as a source of broad-spectrum health-promoting biological activities. However, the bioactivity of these species has not been elucidated. We aimed to confirm the antioxidant, antiviral, and anti-inflammatory effects of Tetraselmis sp. extract (TEE). TEE showed 2,2-diphenyl-1-picryl-hydrazyl-hydrate radical and hydrogen peroxide scavenging activities and reduced plaque formation in Vero E6 cells infected with vaccinia virus. TEE treatment also significantly inhibited nitric oxide (NO) production and improved cell viability in lipopolysaccharide (LPS)-induced RAW264.7 cells. These anti-inflammatory effects were further analyzed in LPS-induced RAW 264.7 cells and the zebrafish model. Further, TEE reduced induced NO synthase expression and proinflammatory cytokine release, including tumor necrosis factor-α, interleukin-6, and interleukin-1β, through MAPKs and NF-κB-dependent mechanisms. Further analysis revealed that TEE increased the survival rate and reduced cell death and NO production in an LPS-stimulated zebrafish model. Further, high-performance liquid chromatography revealed a strong presence of the carotenoid lutein in TEE. Overall, the results suggest that lutein-enriched TEE may be a potent antioxidant, antiviral, and anti-inflammatory agent that could be sustainably utilized in industrial applications. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 21070369 1660-3397 |
| Relation: | https://www.mdpi.com/1660-3397/21/7/369; https://doaj.org/toc/1660-3397 |
| DOI: | 10.3390/md21070369 |
| Access URL: | https://doaj.org/article/59cf2537489b4366a5e80e562ebe868a |
| Accession Number: | edsdoj.59cf2537489b4366a5e80e562ebe868a |
| Database: | Directory of Open Access Journals |
| ISSN: | 21070369 16603397 |
|---|---|
| DOI: | 10.3390/md21070369 |
| Published in: | Marine Drugs |
| Language: | English |