Bibliographic Details
| Title: |
Comparison of SARS-CoV-2 spike-specific IgA and IgG in nasal secretions, saliva and serum |
| Authors: |
Oscar Bladh, Katherina Aguilera, Ulrika Marking, Martha Kihlgren, Nina Greilert Norin, Anna Smed-Sörensen, Margaret Sällberg Chen, Jonas Klingström, Kim Blom, Michael W. Russell, Sebastian Havervall, Charlotte Thålin, Mikael Åberg |
| Source: |
Frontiers in Immunology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
SARS-CoV-2, Covid-19, vaccines, mucosal immunity, antibodies, secretory IgA, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
IntroductionSeveral novel vaccine platforms aim at mucosal immunity in the respiratory tract to block SARS-CoV-2 transmission. Standardized methods for mucosal sample collection and quantification of mucosal antibodies are therefore urgently needed for harmonized comparisons and interpretations across mucosal vaccine trials and real-world data.MethodsUsing commercial electrochemiluminescence antibody panels, we compared SARS-CoV-2 spike-specific IgA and IgG in paired saliva, nasal secretions, and serum from 1048 healthcare workers with and without prior infection.ResultsSpike-specific IgA correlated well in nasal secretions and saliva (r>0.65, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2024.1346749/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2024.1346749 |
| Access URL: |
https://doaj.org/article/a59bbfa69e1c41f9b56f87eee6cfdce7 |
| Accession Number: |
edsdoj.59bbfa69e1c41f9b56f87eee6cfdce7 |
| Database: |
Directory of Open Access Journals |
