Academic Journal
Integrated environmental and health economic assessments of novel xeno-keratografts addressing a growing public health crisis
| Title: | Integrated environmental and health economic assessments of novel xeno-keratografts addressing a growing public health crisis |
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| Authors: | Mustafa Ali, Peter R. Corridon |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Xeno-keratoplasty, Corneal transplantation, Environmental impact, Cost-effectiveness analysis, Slaughterhouse waste, Circular economy, Medicine, Science |
| More Details: | Abstract Tissue scarcity poses global challenges for corneal transplantation and public health. Xeno-keratoplasty using animal-derived tissues offers a potential solution, but its environmental and economic implications remain unclear. This study evaluated two xeno-keratoplasty procedures at a single institution: (1) native corneas (Option 1) and (2) tissue-engineered corneal scaffolds derived from slaughterhouse waste (Option 2). Life cycle assessment (LCA) quantified environmental impacts across 18 midpoint indicators, while cost-effectiveness analysis (CEA) incorporated cost and environmental impact using two approaches. Option 1 exhibited significantly lower environmental impact than Option 2 across most indicators, primarily due to the energy and equipment demands of cell culture in Option 2. Both CEA approaches (carbon offset pricing and utility decrement) demonstrated cost-effectiveness dominance for Option 1. Xeno-keratoplasty using native corneas (Option 1) appears more environmentally and economically favorable than tissue-engineered scaffolds (Option 2) in the current analysis. Future studies could explore diverse xeno-keratoplasty techniques for optimizing sustainability. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-77783-y |
| Access URL: | https://doaj.org/article/a58abe49af8a4092863aea0aa3d43fdd |
| Accession Number: | edsdoj.58abe49af8a4092863aea0aa3d43fdd |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-77783-y |
| Published in: | Scientific Reports |
| Language: | English |