Academic Journal
Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models
| Title: | Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models |
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| Authors: | Sun Young Moon, Kwang Dong Kim, Jiyun Yoo, Jeong-Hyung Lee, Cheol Hwangbo |
| Source: | Molecules, Vol 26, Iss 9, p 2824 (2021) |
| Publisher Information: | MDPI AG, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Organic chemistry |
| Subject Terms: | inflammatory bowel disease (IBD), janus kinase (JAK), signal transducer and activator of transcription (STAT), phytochemicals, Organic chemistry, QD241-441 |
| More Details: | Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that consists of Crohn’s disease (CD) and ulcerative colitis (UC). Cytokines are thought to be key mediators of inflammation-mediated pathological processes of IBD. These cytokines play a crucial role through the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signaling pathways. Several small molecules inhibiting JAK have been used in clinical trials, and one of them has been approved for IBD treatment. Many anti-inflammatory phytochemicals have been shown to have potential as new drugs for IBD treatment. This review describes the significance of the JAK–STAT pathway as a current therapeutic target for IBD and discusses the recent findings that phytochemicals can ameliorate disease symptoms by affecting the JAK–STAT pathway in vivo in IBD disease models. Thus, we suggest that phytochemicals modulating JAK–STAT pathways are potential candidates for developing new therapeutic drugs, alternative medicines, and nutraceutical agents for the treatment of IBD. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 26092824 1420-3049 |
| Relation: | https://www.mdpi.com/1420-3049/26/9/2824; https://doaj.org/toc/1420-3049 |
| DOI: | 10.3390/molecules26092824 |
| Access URL: | https://doaj.org/article/58ab9b6042914f86bc3c3755afdc6e81 |
| Accession Number: | edsdoj.58ab9b6042914f86bc3c3755afdc6e81 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 26092824 14203049 |
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| DOI: | 10.3390/molecules26092824 |
| Published in: | Molecules |
| Language: | English |