Academic Journal
MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential
| Title: | MicroRNAs in adipose tissue fibrosis: Mechanisms and therapeutic potential |
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| Authors: | Mei Tian, Yang Zhou, Yitong Guo, Qing Xia, Zehua Wang, Xinying Zheng, Jinze Shen, Junping Guo, Shiwei Duan, Lijun Wang |
| Source: | Genes and Diseases, Vol 12, Iss 4, Pp 101287- (2025) |
| Publisher Information: | KeAi Communications Co., Ltd., 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Medicine (General) LCC:Genetics |
| Subject Terms: | Adipose tissue fibrosis, Adipose-derived stem cell, Extracellular matrix, miRNAs, Signaling pathways, Medicine (General), R5-920, Genetics, QH426-470 |
| More Details: | Adipose tissue fibrosis, characterized by abnormal extracellular matrix deposition within adipose tissue, signifies a crucial indicator of adipose tissue malfunction, potentially leading to organ tissue dysfunction. Various factors, including a high-fat diet, non-alcoholic fatty liver disease, and insulin resistance, coincide with adipose tissue fibrosis. MicroRNAs (miRNAs) represent a class of small non-coding RNAs with significant influence on tissue fibrosis through diverse signaling pathways. For instance, in response to a high-fat diet, miRNAs can modulate signaling pathways such as TGF-β/Smad, PI3K/AKT, and PPAR-γ to impact adipose tissue fibrosis. Furthermore, miRNAs play roles in inhibiting fibrosis in different contexts: suppressing corneal fibrosis via the TGF-β/Smad pathway, mitigating cardiac fibrosis through the VEGF signaling pathway, reducing wound fibrosis via regulation of the MAPK signaling pathway, and diminishing fibrosis post-fat transplantation via involvement in the PDGFR-β signaling pathway. Notably, the secretome released by miRNA-transfected adipose-derived stem cells facilitates targeted delivery of miRNAs to evade host immune rejection, enhancing their anti-fibrotic efficacy. Hence, this study endeavors to elucidate the role and mechanism of miRNAs in adipose tissue fibrosis and explore the mechanisms and advantages of the secretome released by miRNA-transfected adipose-derived stem cells in combating fibrotic diseases. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3042 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352304224000849; https://doaj.org/toc/2352-3042 |
| DOI: | 10.1016/j.gendis.2024.101287 |
| Access URL: | https://doaj.org/article/5896c7ae5e5c4d25aa5d7f2ae02d27f2 |
| Accession Number: | edsdoj.5896c7ae5e5c4d25aa5d7f2ae02d27f2 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523042 |
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| DOI: | 10.1016/j.gendis.2024.101287 |
| Published in: | Genes and Diseases |
| Language: | English |