Academic Journal
Bone Disease in Long-Term Lung Transplant Survivors
| Title: | Bone Disease in Long-Term Lung Transplant Survivors |
|---|---|
| Authors: | Giorgia Grassi, Elisa Cairoli, Lucrezia Maria Silvana Gentile, Iacopo Chiodini, Marta Zampogna, Alberto Ghielmetti, Letizia Corinna Morlacchi, Valeria Rossetti, Lorenzo Rosso, Ilaria Righi, Mario Nosotti, Maura Arosio, Francesco Blasi, Cristina Eller Vainicher |
| Source: | Life, Vol 13, Iss 4, p 928 (2023) |
| Publisher Information: | MDPI AG, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Science |
| Subject Terms: | lung transplantation, trabecular bone score, vertebral fractures, cystic fibrosis, Science |
| More Details: | Background: During the first two years after lung transplantation (LTx), the incidence of fragility fractures (FX) is estimated to be 15–50% and it is lower in patients with cystic fibrosis (CF) as compared with other end-stage lung diseases (nCF). The aim of our study is to compare the skeletal outcomes, after the first 2 years post-LTx, in long-term survivors with CF and nCF. Materials and Methods: We evaluated the FX rate, the changes in bone mineral density (BMD) and trabecular bone score (TBS) in 68 patients (38 CF and 30 nCF) who underwent LTx in our center and with a follow-up after LTx longer than 5 years (7.3 ± 2.0 years). Results: After the second year post-LTx: (i) the FX rate was lower than during the first two years post-LTx (4.4 vs. 20.6%, p = 0.004), with no difference between CF and nCF patients (5.3 vs. 3.3%, p = 0.589); (ii) BMD at lumbar spine, femoral neck and total hip remained stable (−1.6 ± 1.0 vs. −1.4 ± 1.1, p = 0.431, −1.8 ± 0.9 vs. −1.9 ± 0.9, p = 0.683, −1.5 ± 0.9 vs. −1.4 ± 0.9, p = 0.678, respectively) as well as TBS (1.200 ± 0.124 vs. 1.199 ± 0.205, p = 0.166). Conclusions: After the second year post-LTx, the skeletal complications become less frequent and have similar incidence in patients with CF and nCF. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 13040928 2075-1729 |
| Relation: | https://www.mdpi.com/2075-1729/13/4/928; https://doaj.org/toc/2075-1729 |
| DOI: | 10.3390/life13040928 |
| Access URL: | https://doaj.org/article/e5844c0793fd4a758f9279397f8768ca |
| Accession Number: | edsdoj.5844c0793fd4a758f9279397f8768ca |
| Database: | Directory of Open Access Journals |
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| ISSN: | 13040928 20751729 |
|---|---|
| DOI: | 10.3390/life13040928 |
| Published in: | Life |
| Language: | English |