| Title: |
Increased high molecular weight adiponectin and lean mass during tocilizumab treatment in patients with rheumatoid arthritis: a 12-month multicentre study |
| Authors: |
Eric Toussirot, Hubert Marotte, Denis Mulleman, Grégoire Cormier, Fabienne Coury, Philippe Gaudin, Emmanuelle Dernis, Christine Bonnet, Richard Damade, Jean-Luc Grauer, Tassadit Ait Abdesselam, Caroline Guillibert-Karras, Frédéric Lioté, Pascal Hilliquin, Antoinette Sacchi, Daniel Wendling, Benoît Le Goff, Marc Puyraveau, Gilles Dumoulin |
| Source: |
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-13 (2020) |
| Publisher Information: |
BMC, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Diseases of the musculoskeletal system |
| Subject Terms: |
Adiponectin, Cardiovascular risk, Rheumatoid arthritis, Tocilizumab, Body composition, Diseases of the musculoskeletal system, RC925-935 |
| More Details: |
Abstract Background Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) disease. Adiponectin is involved in the metabolism of glucose and lipids with favourable effects on CV disease, especially its high molecular weight (HMW) isoform. Body composition changes are described in RA with various phenotypes including obesity. The effects of tocilizumab on serum adiponectin and body composition, especially fat mass, in patients with RA are not well determined. Methods Patients with active RA despite previous csDMARDs and/or bDMARDs and who were tocilizumab naïve were enrolled in a multicentre open-label study. They were evaluated at baseline, 1, 3, 6 and 12 months. Clinical assessment included body mass index (BMI) and anthropometric measurements. Lipid and metabolic parameters, serum adiponectin (total and HMW), leptin, resistin and ghrelin were measured at each time point. Body composition (lean mass, fat mass, % fat, fat in the android and gynoid regions) was evaluated at baseline, 6 and 12 months. Results One hundred seven patients were included. Both total and HMW adiponectin significantly increased from baseline to month 3, peaking respectively at month 3 (p = 0.0105) and month 1 (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1478-6362 |
| Relation: |
http://link.springer.com/article/10.1186/s13075-020-02297-7; https://doaj.org/toc/1478-6362 |
| DOI: |
10.1186/s13075-020-02297-7 |
| Access URL: |
https://doaj.org/article/57fa5655c0c64ea0aba3f37d52baaf03 |
| Accession Number: |
edsdoj.57fa5655c0c64ea0aba3f37d52baaf03 |
| Database: |
Directory of Open Access Journals |
