Genetic exchange and reassignment in Porphyromonas gingivalis

Bibliographic Details
Title:	Genetic exchange and reassignment in Porphyromonas gingivalis
Authors:	Ingar Olsen, Tsute Chen, Gena D Tribble
Source:	Journal of Oral Microbiology, Vol 10, Iss 1 (2018)
Publisher Information:	Taylor & Francis Group, 2018.
Publication Year:	2018
Collection:	LCC:Infectious and parasitic diseases LCC:Microbiology
Subject Terms:	Porphyromonas gingivalis, adaptability, survival, periodontitis, keystone pathogen hypothesis, homeostasis, dysbiosis, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
More Details:	Porphyromonas gingivalis is considered a keystone pathogen in adult periodontitis but has also been associated with systemic diseases. It has a myriad of virulence factors that differ between strains. Genetic exchange and intracellular genome rearrangements may be responsible for the variability in the virulence of P. gingivalis. The present review discusses how the exchange of alleles can convert this bacterium from commensalistic to pathogenic and potentially shapes the host-microbe environment from homeostasis to dysbiosis. It is likely that genotypes of P. gingivalis with increased pathogenic adaptations may spread in the human population with features acquired from a common pool of alleles. The exact molecular mechanisms that trigger this exchange are so far unknown but they may be elicited by environmental pressure.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2000-2297 20002297
Relation:	https://doaj.org/toc/2000-2297
DOI:	10.1080/20002297.2018.1457373
Access URL:	https://doaj.org/article/57e98f298e984d49a232efd114833239
Accession Number:	edsdoj.57e98f298e984d49a232efd114833239
Database:	Directory of Open Access Journals
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More Details
ISSN:	20002297
DOI:	10.1080/20002297.2018.1457373
Published in:	Journal of Oral Microbiology
Language:	English